Skip to main content
Fig. 2 | Molecular Medicine

Fig. 2

From: Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study

Fig. 2

Summarized results on differential gene expression after 0.05 Gray. Differentially expressed genes in irradiated compared to sham-irradiated fibroblasts from donors with a first primary neoplasm only (N1), donors with at least one second primary neoplasm (N2+), and cancer-free controls (N0) 4 h after exposure to 0.05 Gray (false discovery rate adjusted p-value < 0.05). The data are presented for the crude model, model 1 (considering age at sampling and sex), and model 2 [considering age at sampling, sex, age at and year of diagnosis of the first neoplasm, and tumor type (not applicable for N0 data)]. In total, 14,756 genes were detected in the samples. Shown are A the proportion of up- and downregulated genes stratified by dose, group, and model, B volcano plots for the results of model 1, and C top 10 genes with regard to p-value, stratified by direction of log2 fold-change

Back to article page