Skip to main content
Fig. 4 | Molecular Medicine

Fig. 4

From: Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study

Fig. 4

Results of Ingenuity Pathway Analysis. Overview of affected (false discovery rate adjusted at p-value < 0.05) and (in-) activated pathways (|z|≥ 2), predicted upstream effectors, downstream biofunctions and diseases, and observed molecular networks after irradiation with a low (0.05 Gray) or a high dose (2 Gray) ordered by p-value. For molecular networks, the network score instead of a p-value and no z-score was calculated by Ingenuity Pathway Analysis and is given inside the tiles. For each combination of dose, model, and donor group, the top functions of the network with a score > 10 is presented, except for N2+ after 2 Gray, where two networks had a score above 10 in all models. On the right-hand side, the functions associated with the networks are shown. *p-value < 0.05, **p-value < 0.01, ***p-value < 0.001. Model 1: considering age at sampling and sex, model 2: considering age at sampling, sex, age at and year of diagnosis of the first neoplasm, and tumor type (not used with data from N0), N0 = fibroblasts of cancer-free controls, N1 = fibroblasts of childhood-cancer survivors, N2+  = fibroblasts of childhood-cancer survivors with at least one second primary neoplasm

Back to article page