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Table 2 Overview of genes for the analysis of interactions between the effect of the radiation dose and the donor group

From: Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study

 

Gene

Genename

N2+ /N1 vs. N0

N1 vs. N0

N2+ vs. N0

N2+ vs. N1

FDR

LFC

FDR

LFC

FDR

LFC

FDR

LFC

0.05 Gray

RAB41

RAB41, member RAS oncogene family

0.404

− 0.567

0.166

− 0.757

–

–

–

–

CAMTA2

Calmodulin binding transcription activator 2

0.404

0.074

–

–

0.056

0.101

-

-

PATZ1

POZ/BTB and AT hook containing zinc finger 1

0.404

− 0.077

–

–

–

–

–

–

RIPK1

Receptor interacting serine/threonine kinase 1

0.404

− 0.060

–

–

–

–

–

–

SPDYE3

Speedy/RINGO cell cycle regulator family member E3

0.404

− 0.202

–

–

–

–

–

–

ZNF226

Zinc finger protein 226

0.404

− 0.097

–

–

–

–

–

–

AGAP9

ArfGAP with GTPase domain, ankyrin repeat and PH domain 9

–

–

0.359

0.826

–

–

–

–

PDZD2

PDZ domain containing 2

–

–

0.727

0.758

–

–

–

–

COL23A1

Collagen type XXIII alpha 1 chain

–

–

-

–

0.536

0.840

–

–

ADNP-AS1

ADNP antisense RNA 1

–

–

–

–

–

–

0.457

0.533

ALG9

ALG9 alpha-1,2-mannosyltransferase

–

–

–

–

–

–

0.457

-0.171

CLUHP3

Clustered mitochondria homolog pseudogene 3

–

–

–

–

–

–

0.457

0.553

DLEU2

Deleted in lymphocytic leukemia 2

–

–

–

–

–

–

0.457

-0.378

LOC101927630

Uncharacterized LOC101927630

–

–

–

–

–

–

0.457

-0.824

MYO7B

Myosin VIIB

–

–

–

–

–

–

0.457

0.877

TFCP2

Transcription factor CP2

–

–

–

–

–

–

0.457

-0.071

TIAF1

TGFB1-induced anti-apoptotic factor 1

–

–

–

–

–

–

0.457

0.342

LINC02257

Long intergenic non-protein coding RNA 2257

–

–

–

–

–

–

0.624

0.777

2 Gray

LINC00601

Long intergenic non-protein coding RNA 601

0.003

0.552

0.001

0.692

–

–

–

–

COBLL1

Cordon-bleu WH2 repeat protein like 1

0.003

0.258

0.005

0.282

–

–

–

–

SESN2

Sestrin 2

0.003

0.218

0.015

0.229

0.193

0.208

–

–

BIN3

Bridging integrator 3

0.003

−0.130

0.024

− 0.131

0.193

-0.128

–

–

TNFRSF10A

TNF receptor superfamily member 10a

0.003

0.317

0.001

0.409

–

–

–

–

EEF1AKNMT

eEF1A lysine and N-terminal methyltransferase

0.013

0.101

0.013

0.118

–

–

–

–

MGAT4A

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

0.093

0.805

0.427

0.760

0.324

0.851

–

–

CTPS2

CTP synthase 2

0.130

− 0.113

–

–

–

–

–

–

BTG2

BTG anti-proliferation factor 2

0.157

0.173

0.004

0.256

–

–

–

–

ZNF598

Zinc finger protein 598

0.157

− 0.105

–

–

–

–

–

–

IP6K3

Inositol hexakisphosphate kinase 3

–

–

0.339

− 0.787

–

–

–

–

PDZD2

PDZ domain containing 2

–

–

0.434

0.755

–

–

–

–

ADAMTS17

ADAM metallopeptidase with thrombospondin type 1 motif 17

–

–

–

–

–

–

0.469

− 0.833

DUOXA1

Dual oxidase maturation factor 1

–

–

–

–

0.324

0.750

0.472

0.828

EDARADD

EDAR associated death domain

–

–

–

–

0.324

0.769

–

–

HAS3

Hyaluronan synthase 3

–

–

–

–

–

–

0.469

0.711

LOC100505622

Uncharacterized LOC100505622

–

–

–

–

–

–

0.469

− 0.737

TSEN54

tRNA splicing endonuclease subunit 54

–

–

–

–

0.193

− 0.175

–

–

ZNF2

Zinc finger protein 2

–

–

–

–

–

–

0.469

− 0.140

  1. Genes were selected if their p-value was among the top 0.01% of that data set, p-value < 0.15, or log2 fold-change >|0.75|
  2. Data adjusted for age at sampling and sex (model 1) are shown. Genes with p-value < 0.05 adjusted for false discovery rate (FDR) are presented in bold text
  3. N2+ = fibroblasts of donors with a first primary neoplasm in childhood and at least one second primary neoplasm, N1 = fibroblasts of donors with a first primary neoplasm in childhood, N0 = fibroblasts of cancer-free controls; LFC = log2 fold-change