Fig. 2

The characteristics of the intracellular metabolic data. A partial least square discriminant analysis (PLS-DA) between the sh-NC group and sh-FoxO3a group. B The student t-test analysis showed that 25 metabolites differed between the sh-NC and knockdown groups. C The area under the receiver operating characteristic (ROC) curve for intracellular metabolites. There were 12 metabolites under the ROC curve greater than 90%, mainly amino acids and long-chain unsaturated fatty acids. D The R package of PAPi. Only statistically significant differences in metabolites and low false discovery rate (P < 0.05 by the Student's t-test) are illustrated