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Fig. 6 | Molecular Medicine

Fig. 6

From: A novel role of FoxO3a in the migration and invasion of trophoblast cells: from metabolic remodeling to transcriptional reprogramming

Fig. 6

FoxO3a regulates HTR8/SVneo cells migration progress. A The heatmap illustrates the copy numbers of mRNAs. Red represents higher transcription, and green represents lower transcription. B Enriched Gene Ontology (GO) analysis illustrated that migration of HTR8/SVneo cells was the most affected biological process after FoxO3a exhaustion. C Correlation analysis between transcriptomics and metabolomics. Red represents positive correlation, and blue represents negative correlation. D qPCR shows reduced expression of the genes (COX-2 and MMP9). Only the results showing statistically significant Student’s t-test (P < 0.05) and minimum false discovery rate (q < 0.05) are shown, n = 3, **P < 0.01 and ***P < 0.001

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