Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients

Sasso, Etianne Martini; Muraki, Katsuhiko; Eaton-Fitch, Natalie; Smith, Peter; Lesslar, Olivia Ly; Deed, Gary; Marshall-Gradisnik, Sonya

doi:10.1186/s10020-022-00528-y

Molecular Medicine

Table 2 Participant quality of life, disability scores and serology

From: Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients

	HC	ME/CFS	Post COVID-19 condition	P-value
SF-36 (%)
Physical functioning	100.0 ± 0.0	39.00 ± 22.75	52.0 ± 31.54	0.006
Physical role	100.0 ± 0.0	22.50 ± 14.39	26.25 ± 27.03	0.008
Pain	94.00 ± 8.94	46.50 ± 17.46	38.0 ± 18.40	0.008
General health	77.50 ± 11.26	26.67 ± 12.0	57.5 ± 14.25	0.005
Social functioning	95.00 ± 11.18	27.50 ± 24.04	22.50 ± 31.12	0.009
Emotional role	93.27 ± 7.00	66.67 ± 36.80	61.67 ± 48.81	0.712
Emotional wellbeing	70.00 ± 12.75	63.00 ± 17.53	62.00 ± 24.39	0.853
Vitality	66.25 ± 19.06	10.0 ± 9.48	13.75 ± 6.85	0.007
WHO DAS (%)
Communication and understanding	5.83 ± 9.13	48.33 ± 10.87	44.17 ± 21.97	0.011
Mobility	2.00 ± 4.47	38.00 ± 21.09	35.00 ± 23.18	0.010
Self-care	0.0 ± 0.0	12.50 ± 17.12	1.25 ± 2.79	0.265
Interpersonal relationships	3.75 ± 5.59	41.25 ± 15.05	16.25 ± 12.96	0.008
Life activities	0.0 ± 0.0	52.65 ± 33.25	58.75 ± 32.65	0.007
Participation in society	3.75 ± 5.59	57.51 ± 11.19	46.87 ± 26.43	0.011
Full blood count
White cell count (4.0–11.0 × 10⁹/L)	5.94 ± 0.72	5.16 ± 1.37	5.48 ± 1.22	0.522
Lymphocytes (1.0–4.0 × 10⁹/L)	1.87 ± 0.34	1.48 ± 0.30	1.75 ± 0.49	0.247
Neutrophils (2.0–8.0 × 10⁹/L)	3.42 ± 0.40	3.09 ± 1.08	3.20 ± 0.83	0.623
Monocytes (0.1–1.0 × 10⁹/L)	0.47 ± 0.16	0.39 ± 0.15	0.38 ± 0.12	0.432
Eosinophils (< 0.6 × 10⁹/L)	0.15 ± 0.87	0.15 ± 0.76	0.10 ± 0.36	0.606
Basophils (< 0.2 × 10⁹/L)	0.04 ± 0.02	0.03 ± 0.01	0.04 ± 0.01	0.308
Platelets (140–400 × 10⁹/L)	298.6 ± 25.83	239.60 ± 40.54	263.00 ± 50.40	0.093
Red cell count (3.8–5.2 × 10¹²/L)	4.48 ± 0.37	4.96 ± 0.47	4.67 ± 0.41	0.264
Haematocrit (0.33–0.47)	0.40 ± 0.02	0.44 ± 0.04	0.41 ± 0.03	0.102
Haemoglobin (115–160 g/L)	131.8 ± 10.89	146.4 ± 10.74	139.8 ± 12.32	0.171

Data presented as mean ± SD. Reference ranges for full blood count parameters have been included in the table. Values of p < 0.05 are bolded. HC healthy control, ME/CFS myalgic encephalomyelitis/chronic fatigue syndrome, SF-36 36-item short form health survey, WHO World Health Organization, DAS disability assessment schedule

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