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Fig. 2 | Molecular Medicine

Fig. 2

From: Bone marrow mesenchymal stem cell-derived exosomes shuttling miR-150-5p alleviates mechanical allodynia in rats by targeting NOTCH2 in microglia

Fig. 2

BMSC-exosomes reduce mechanical allodynia of L5 SNL rats. A Localization of BMSC-exosomes by fluorescence staining; Hind paw PWT (B) and PWL (C) of SNL rats on days 0, 1, 3, 5, 10, 15, and 20 after surgery; (D) TUNEL staining assessed the apoptosis in rat SDH; (E) ELISA measured the expression of TNF-α, IL-1β, and IL-6 in rat SDH. Data were shown as mean ± standard deviation. N = 6. *P < 0.05, vs. the sham group; #P < 0.05, vs. the SNL group. BMSC bone marrow mesenchymal stem cell, SNL spinal nerve ligation, PWT paw withdrawal threshold, PWL paw withdrawal latency, SDH spinal dorsal horn

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Molecular Medicine

ISSN: 1528-3658