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Fig. 4 | Molecular Medicine

Fig. 4

From: Bone marrow mesenchymal stem cell-derived exosomes shuttling miR-150-5p alleviates mechanical allodynia in rats by targeting NOTCH2 in microglia

Fig. 4

BMSC-exosomes downregulate microglial NOTCH2 expression. RT-qPCR (A) and western blots (B) were used to detect NOTCH2 expression in microglial cells after BMSC-exosome treatment; RT-qPCR (C), western blotting (D), and immunohistochemistry (E) were used to detect the expression of NOTCH2 in SDH; (F) Double immunofluorescence staining was used to localize NOTCH2. Data were shown as mean ± standard deviation. N = 6. *P < 0.05, vs. the sham group; #P < 0.05, vs. the SNL group. BMSC bone marrow mesenchymal stem cell, SDH spinal dorsal horn, SNL spinal nerve ligation

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Molecular Medicine

ISSN: 1528-3658