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Fig. 4 | Molecular Medicine

Fig. 4

From: Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses

Fig. 4

IL-1β induced vagus nerve electrical activity requires TRPA1 and IL1R1 but not TRPV1. a, c Representative recordings of the vagus nerve signals shown for a TRPA1fl/fl littermate control mice and c Syn-Cre/TRPA1fl/fl mice starting before (baseline) and after IL-1β administration (350 ng/kg, post-IL-1β). Examples of the baseline and post-IL-1β administration responses are shown. Data is representative of 5–8 animals per group. b, d Total spike count during recordings over the entire 5-min pre- and 5-min post-IL-1β administration in b TRPA1fl/fl littermate control mice (n = 8) and d Syn-Cre/TRPA1fl/fl mice (n = 5). Data is presented as individual mouse data point. e, g Representative recordings of the vagus nerve signals shown for e TRPA1-Cre/IL1R1fl/fl mice and g TRPV1 KO mice starting before (baseline) and after IL-1β administration (350 ng/kg, Post-IL-1β). Data is representative of 6–7 animals per group. f, h Total spike count over the entire 5-min pre- and 5-min post-IL-1β administration recordings in TRPA1-Cre/IL-1R1fl/fl mice (n = 6) and TRPV1 KO mice (n = 7). Data are represented as individual mouse data points

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