Fig. 6

TRPA1 is required to improve survival in experimental sepsis. a–c Wild type (B6.129PF) and TRPA1 KO mice were subjected to cecal ligation and puncture (CLP) procedure. a Murine Sepsis Score (MSS) assessed in wildtype (B6.129PF; n = 15) and TRPA1 KO mice (n = 12–16) on day 3 post-CLP. Data is presented as individual mouse data points with mean ± SEM. Unpaired t-test with Welch’s correction. ****p < 0.0001. b Murine sepsis scores assessed in wildtype (B6.129PF; n = 15) and TRPA1 KO mice (n = 12–16) on pre-CLP (Day 0) and post-CLP days (day 3, 4, 5, and 6). Data is presented as mean ± SEM. Mixed effects analysis; ****p < 0.0001. c Sepsis mortality rate in wildtype (B6.129PF; n = 15) and TRPA1 KO mice (n = 16) subjected to sublethal CLP. Sublethal CLP protects wildtype mice with no mortality, but induces 25% mortality in TRPA1 KO mice by day 4. Log-rank (Mantel–Cox) test, *p < 0.05