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Fig. 1 | Molecular Medicine

Fig. 1

From: Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia

Fig. 1

Accumulation of DNA double-strand breaks (DSBs) and increased expression of p21 in lung tissue of bronchopulmonary dysplasia (BPD) rats. A H&E staining visualized with a light microscope to observe morphological changes in lung tissue (scale bar = 100 μm). B Immunofluorescence staining of γ-H2AX (red) and DAPI (blue) in rat lung tissue in model and control groups at different time points (3, 7 and 14 days). (Scale bar = 50 μm.) (I–III) Enlarged image of γ-H2AX. Scale bar = 10 μm. C Expression levels of γ-H2AX in rat lung tissue in model and control groups at different time points (3, 7 and 14 days) detected by western blot. D Expression levels of p21 in rat lung tissue in model and control groups at 14 days detected by western blot (E) Comparison of Radial alveolar counts (RAC) for lung tissue between the two groups. F Level of 8-OHdG in rat lung tissue in model and control groups (C = control group, M = model group). *p < 0.05, **p < 0.01

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