Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia

Table 3 Gene expression analysis by DNA damage signaling pathway-based PCR array

Gene bank	Symbol	Gene function	Fold regulation model/control		p value
Gene bank	Symbol	Gene function	Up	Down	p value
NM_012514	Brca1	ATM / ATR signaling	1.55		0.045666
NM_001107396	Cdc25c	Cell cycle	3.13		0.005991
NM_080782	Cdkn1a	Cell cycle	3.53		0.002586
NM_001106201	Dclre1a	Nucleotide excision repair	1.60		0.008727
NM_001108455	Fanca	Fanconi anemia pathway	1.63		0.031054
NM_001001719	Fancd2	Fanconi Anemia pathway	1.66		0.029674
NM_001077640	Gadd45g	Apoptosis	2.05		0.016492
NM_012861	Mgmt	DNA repair	3.30		0.002173
NM_012557	Fancc	Fanconi anemia pathway		− 1.67	0.021384
NM_024134	Ddit3	Apoptosis		− 1.70	0.001880
XM_001059437	Mbd4	Base excision repair		− 1.80	0.009073
XM_001065837	Msh3	Mismatch repair		− 2.24	0.011564
NM_001105728	Nthl1	Base excision repair		− 1.63	0.027792
NM_001009535	Pms1	Mismatch repair		− 1.61	0.000344
NM_001105825	Ppm1d	Negative feedback regulation of DNA damage repair		− 1.51	0.021103
NM_001106419	Rad1	Double-strand break repair		− 1.90	0.000737
NM_001106617	Rad52	Double-strand break repair		− 1.77	0.003632
NM_031583	Smc3	Double-strand break repair		− 1.59	0.006429
XM_214361	Wrn	Base excision repair		− 1.60	0.028017

p value of < 0.05, fold difference > 1.5
Relative expression profiles of genes associated with the DNA damage signaling pathway in model and control rat lung tissues. Genes were considered to be differentially expressed if there was a > 1.5-fold difference in gene expression, with a threshold p value of < 0.05

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