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Fig. 2 | Molecular Medicine

Fig. 2

From: S100 proteins in cardiovascular diseases

Fig. 2

Function of S100A1 in cardiomyocytes and endothelial cells. A In cardiomyocytes, S100A1 regulates calcium homeostasis by enhancing SERCA2 activity and controlling the function of RyR2. The regulation of RyR2 by S100A1 reduces Ca2+ leakage from the sarcoplasmic reticulum in diastole and increases Ca2+ release from the sarcoplasmic reticulum in systole. S100A1 also regulates sarcomere stiffness and Ca2+ response. Moreover, S100A1 regulates the mitochondrial function and energy metabolism of cardiomyocytes and inhibits their apoptosis. Finally, S100A1 inhibits ventricular remodeling and prevents arrhythmia. B The main role of S100A1 in endothelial cells is the control of Ca2+ uptake and release from the endoplasmic reticulum and the regulation of NO balance

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