Fig. 5From: S100 proteins in cardiovascular diseasesVEGF secreted by cardiomyocytes activates the response of the RAGE receptor to S100B, promotes the release of fibroblast growth factor, and induces the proliferation of cardiac fibroblasts. In addition, the interaction between S100B and RAGE activates p53 and initiates apoptosis through the MEK-ERK1/2 pathwayBack to article page