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Fig. 2 | Molecular Medicine

Fig. 2

From: Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Fig. 2

Pathway enrichment of pre-cystic and cystic transcriptomic signatures. Bubbleplots of pathway enrichment using GO, Reactome, and WikiPathways of upregulated and downregulated genes from the (A) pre-cystic P70 transcriptomic signature, (B) cystic P21 transcriptomic signature, and (C) cystic P28 transcriptomic signature, with point size dependent on the number of query genes matching to each term and color dependent on the p-value. Treemaps display the enrichment hierarchy, using Wang similarity to reduce GO:BP term redundancy with parent terms consisting of largest boxes and enriched child terms within for each signature, and varying child terms reflecting term size for (D) pre-cystic P70 signature (E) cystic P21 transcriptomic signature, and (F) cystic P28 transcriptomic signature

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Molecular Medicine

ISSN: 1528-3658