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Fig. 2 | Molecular Medicine

Fig. 2

From: Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment

Fig. 2

Examples illustrate the cell-to-cell communications CAFs participated. To reshape the TME, CAFs could interact with other cells by direct cell-cell contacts or indirect mechanisms, including: (1) gap junctions and (2) contact-dependent signaling both belong to direct cell junctions, (3) secreted soluble factors and EVs-mediated cell interactions, and (4) CAF-mediated ECM remodeling

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Molecular Medicine

ISSN: 1528-3658