Table 3 Compounds contained in exosome-based therapeutic strategies

Heparin

Inhibit the uptake of exosome by cancer cells via targeting cell-surface heparan sulphate proteoglycans

Christianson et al. (2013)

Cytochalasin D

Inhibit the actin polymerization and suppress the endocytosis of exosomes by cancer cells

Zhao et al. (2016)

Methyl-β-cyclodextrin

Remove cholesterol from membranes and interfere lipid rafts stability to inhibit the uptake of exosomes

Escrevente et al. (2011)

Dynasore

Inhibit the exosomes endocytosis mediated by dynamin

Kawamoto et al. (2012)

Gefitinib

Involve in a non-classical endocytosis pathway including dynamin and lipid-rafts

Hazan-Halevy et al. (2015)

Tipifarnib

Target RAB27A-participated exosome production or secretion process

Martin et al. (2007)

Manumycin A (MA)

Inhibit neutral sphingomyelinase (nSMase) thus reduce ceramide-regulated exosome release

Datta et al. (2017)