Figure 7

Spatial learning in 12-mo-old Fischer and TgAPPswe male rats. A–D: Hidden version of the Morris water maze for Fischer (□) and TgAPPswe (■) male rats. A: Acquisition, mean time (±SEM) to locate the escape platform (P < 0.04). B: Percent time (±SEM) spent in each quadrant for Fischer rats during the probe trial. C: Percent time (±SEM) spent in each quadrant for TgAPPswe rats during the probe trial. P values for B and C derived from Tukey’s pairwise multiple comparison test comparing percent search time in target quadrant with opposite; target quadrant with right; target quadrant with left following one-way ANOVA. D: Latency to cross training site (±SEM) for Fischer and TgAPPswe rats during the probe trial. E: Mean time (±SEM) to locate the escape platform during a visible version of the MWM (P = 0.805). Quadrants are targeted or training quadrant (Trgt), adjacent right, adjacent left, and opposite quadrant (Opp).