Figure 2

FVIIa:TF-induced signal transduction. Upon FVIIa:TF complex formation, PAR2 or a still unknown PAR is proteolytically activated. Subsequently, depending on the cell type, events such as calcium signaling, activation of the MAP kinase pathways, and nuclear translocation of transcription factors such as NF-κB takes place. This will eventually result in the upregulation of a set of mRNAs. Alternatively, the cytoplasmic tail may bind proteins such as actin-binding protein-280 upon phosphorylation. The FVIIa:TF complex may also serve as a scaffold for FXa, targeting PAR1 and PAR2. This will again lead to activation of MAP kinase pathways and transcription. Note that the pathways and genes shown in this figure are those described in the literature, although each specific interaction might result in activation of additional pathways and genes.