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Figure 2 | Molecular Medicine

Figure 2

From: Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation

Figure 2

Inhibition of AII receptor activation (losartan), NADPH oxidase (apocynin), or NOS (NG-nitro-L-arginine) dose-dependently reduced angiotensin-mediated activation of PARP in endothelial cells. Inhibition of xanthine oxidase by allopurinol had no effect on AII-mediated activation of PARP. Results are expressed as mean ± SEM of the % inhibition of PARP activation following 24-h treatment of mouse endothelial cells with on AII (300 µM) with and without various drug concentrations. Statistical significance was determined from 3 separate experiments using Student t test where P < 0.05 was considered significant; *P < 0.05 compared with angiotensin treatment alone.

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