Figure 4
From: Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation
Pharmacological inhibition of PARP with PJ34 prevents (A) or improves (B) the AII-induced endothelial dysfunction. Acetylcholine-induced endothelium-dependent relaxations are shown. Each point of the curve represents mean ± SEM of 6 to 8 experiments in vascular rings. *P < 0.05 compared with control (CO) and †P < 0.05 compared with AII. Animals receiving AII were treated with PJ34 (30 mg/kg/d) from day 0 (A: n = 8) or d 7 (B: n = 6) following AII-releasing minipump implantation for 1 wk.