Figure 5
From: Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation
Evidence of poly(ADP-ribose) formation in the rat aorta after AII infusion. Immunohistochemical staining for poly(ADP-ribose) formation, an indicator of PARP activation, in AII-infused (AII) and INO1001-treated AII-infused rats (AII + INO1001). The evidence of poly(ADP-ribose) accumulation can be seen as dark nuclear staining, indicated by arrows in the endothelial cells. Treatment with INO1001 (right panel) markedly reduced AII-induced PARP activation in the endothelial cells. Similar immunohistochemical profiles were seen in 4 to 5 aortas per group. There was no detectable PARP activation in the control vessels (not shown).