Figure 9
From: Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation
Evidence of poly(ADP-ribose) formation in the heart, aorta, and kidneys of SHR and reversal by enalapril treatment. There was no detectable PARP activation in the control sections. The evidence of poly(ADP-ribose) accumulation can be seen as dark nuclear staining in the myocytes (upper left panel), endothelial cells, and vascular smooth muscle (middle left panel), and tubuli and glomeruli (lower left panel) of SHR. Treatment with enalapril (right panels) markedly reduced PARP activation in the myocytes, endothelial and vascular smooth muscle cells, and also in glomeruli and tubuli. Similar immunohistochemical profiles were seen in 4 to 5 tissue samples per group.