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Figure 5 | Molecular Medicine

Figure 5

From: Biochemical Characterization of Porphobilinogen Deaminase-Deficient Mice During Phenobarbital Induction of Heme Synthesis and the Effect of Enzyme Replacement

Figure 5

Urinary PBG levels following repeated subcutaneous injections of recombinant human PBGD (rhPBGD). PBGD-deficient mice were administered daily intraperitoneally with increasing doses of phenobarbital (75 to 90 mg/kg) for 4 d at 2 occasions (days 1 to 4 and days 8 to 11). The arrows indicate time of phenobarbital (PB) as well as rhPBGD administration. One mouse was administered subcutaneously with rhPBGD twice daily (20 mg/kg) between days 1 and 5. Urine was collected in 24-h fractions and PBG concentrations were expressed as mmol/mol creatinine.

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Molecular Medicine

ISSN: 1528-3658