Figure 1

Effect of in vivo treatment with EGCG on myocardial histology. A: Representative cardiac section from a sham-operated rat displays normal tissue structure. B: After 30 min occlusion and 120 min reperfusion of the left coronary artery (I-R), a marked disruption of the myocardial structure characterized by appearance of extensive necrosis, contraction bands (arrow), and thinning of myofibrils (arrow head) was demonstrated in cardiac sections of a vehicle-treated rat. C: In vivo treatment with EGCG ameliorated myocardial damage. EGCG-treated rats received a bolus dose of EGCG 10 mg/kg at the end of the ischemia period followed by 10 mg/kg/h intravenous infusion for the entire period of reperfusion. Magnification × 100. A similar pattern was seen in 6 to 8 different tissue sections in each experimental group.