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Figure 1 | Molecular Medicine

Figure 1

From: The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

Figure 1

Time course of protein hyperacetylation in LPS-stimulated PBMCs. Resting human PBMCs from a healthy donor were incubated with LPS only (10 ng/mL) or LPS in the presence of ITF2357 (100 nM) or SAHA (100 nM). At the indicated times, the cells were lysed and total protein extracts analyzed by Western blotting using an antibody to acetylated lysines. The results are representative of 1 of 3 donors with similar observations.

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Molecular Medicine

ISSN: 1528-3658