Effect of ITF2357 on ConA-induced hepatitis in C57Bl/6 mice. C57BL/6 mice (10 per group) received either a single oral dose of 1 or 10 mg/kg ITF2357 (100 µL), whereas control mice received water (Controls). After 30 min, all mice received an intravenous injection of ConA (200 µg per mouse). Mean ± SEM serum ALT are shown after 24 hours. *P < 0.05 versus ConA with water vehicle.