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Figure 4 | Molecular Medicine

Figure 4

From: The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

Figure 4

Caspase 3/7 activation and nucleosome formation. Purified monocytes were incubated with and without ITF2357 (as shown under the horizontal axis). After 1 h, LPS (10 ng/mL) was added to some wells. After 24 h, caspase activation and nucleosome formation were assayed. The data are expressed as fold increase (mean ± SEM, n = 3 donors) over monocytes without ITF2357.

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