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Table 2 Sex, age, and ethnicity (fixed effect) contributions to intersubject variation for 43 genes, in decreasing order of percentage of variance explained (equation 3).

From: Limited Dynamic Range of Immune Response Gene Expression Observed in Healthy Blood Donors Using RT-PCR

Gene Percent of Variance Explained by Sex, Age, and Ethnicity P Values for Effect Fold Change Corresponding to Effect Fold Change Corresponding to Age Difference (69 vs. 23 years)
Sex Ethnicity Sex + Ethnicity Age Sex + Age Ethnicity + Age Sex + Ethnicity + Age WM vs. WF HF vs. WF HM vs. WF WF WM HF HM
NFKB1 27.90 0.0022 0.7083 0.1098 0.3335 0.0553 0.1896 0.2572 1.35 −1.04 −1.03 −1.29 −2.48 1.32 1.43
MPO 27.74 0.0128 0.0005 0.0116 0.2260 0.3535 0.8682 0.0909 1.42 1.82 1.31 1.57 1.00 1.43 4.48
IL18 27.46 0.0220 0.6228 0.9333 0.0119 0.0468 0.9150 0.1023 1.25 1.06 1.30 1.97 −1.02 1.88 2.77
MYC 26.91 0.0180 0.0132 0.7298 0.5240 0.1344 0.9658 0.1843 1.31 −1.42 −1.17 −1.21 −2.19 −1.24 1.23
TGFB1 25.88 0.0121 0.0726 0.5024 0.5696 0.0809 0.3451 0.1967 1.22 −1.18 −1.07 −1.13 −1.84 1.21 1.47
TNFSF6 23.90 0.0008 0.0344 0.0123 0.1039 0.0892 0.8499 0.4898 1.62 1.39 1.17 1.78 −1.28 1.61 1.32
LTA 23.87 0.0179 0.8223 0.0131 0.4992 0.1109 0.9253 0.4470 1.32 −1.03 −1.33 −1.22 −2.32 −1.17 −1.27
ELA2 23.65 0.3536 0.0013 0.0998 0.0262 0.2949 0.1695 0.0889 1.24 2.53 1.50 4.21 1.78 1.09 6.94
CD86 21.03 0.0289 0.2781 0.4782 0.1418 0.1509 0.3672 0.3403 1.24 1.13 1.23 1.47 −1.11 2.12 2.42
CD14 20.75 0.0066 0.9157 0.1150 0.1484 0.4972 0.0631 0.6869 1.42 −1.02 −1.05 −1.65 −2.24 1.64 1.71
C1QA 19.11 0.9650 0.2648 0.7856 0.0458 0.1489 0.0286 0.0015 1.01 1.25 1.15 2.51 1.07 −1.89 9.27
GCLC 19.04 0.1281 0.0510 0.4470 0.1961 0.5864 0.4943 0.1936 1.19 1.31 1.33 1.51 1.21 2.10 −1.66
HSPA1A 18.91 0.0208 0.3329 0.8448 0.2111 0.5560 0.1404 0.3747 1.37 −1.17 1.12 −1.58 −2.09 1.46 2.47
TNF 18.22 0.0489 0.6451 0.2638 0.6774 0.8716 0.0660 0.4877 1.44 −1.11 −1.14 −1.23 −1.11 3.34 1.59
HMGB1 17.72 0.0630 0.0047 0.1891 0.2164 0.3968 0.6109 0.9320 1.24 1.50 1.39 1.48 1.05 1.16 −1.31
CYBB 17.34 0.0223 0.9489 0.3272 0.9352 0.2462 0.1217 0.5252 1.31 −1.01 1.05 1.03 −1.56 2.17 2.22
SERPINA1 17.27 0.0730 0.2471 0.9965 0.2167 0.5933 0.0938 0.5365 1.28 −1.21 1.06 −1.59 −2.06 1.66 2.28
MMP9 16.14 0.1858 0.1057 0.3289 0.1730 0.6537 0.5372 0.3199 1.36 −1.57 1.34 −2.39 −3.46 −1.31 2.56
CXCL1 15.91 0.1965 0.1305 0.5228 0.3722 0.4229 0.1961 0.4267 1.18 −1.26 1.09 −1.36 −1.94 1.46 2.02
EGR1 15.53 0.0263 0.3387 0.4572 0.2550 0.0909 0.6418 0.2217 1.33 −1.15 −1.04 1.48 −1.44 1.16 1.54
IL15 15.44 0.4922 0.0501 0.0862 0.3364 0.9222 0.3302 0.2744 1.10 1.37 −1.03 1.42 1.36 2.45 −1.15
DPP4 15.00 0.2114 0.4354 0.4450 0.1223 0.6509 0.1781 0.5079 1.15 −1.11 −1.14 −1.63 −1.95 1.18 −1.70
CD4 14.86 0.0816 0.4197 0.3359 0.9445 0.0935 0.4285 0.4223 1.19 −1.10 −1.11 1.02 −1.77 1.42 1.34
HMOX1 14.81 0.0587 0.8654 0.6194 0.2167 0.0801 0.9441 0.0954 1.27 −1.03 1.10 1.53 −1.44 1.59 3.05
PLA2G7 14.20 0.0865 0.9282 0.7051 0.4431 0.8269 0.0575 0.6794 1.27 1.02 1.17 −1.34 −1.49 2.31 3.07
PLAUR 13.46 0.2046 0.4947 0.9590 0.4582 0.2254 0.6593 0.1645 1.17 −1.10 1.07 −1.28 −2.15 −1.02 1.83
TIMP1 13.33 0.0658 0.5106 0.2000 0.4669 0.1399 0.8392 0.3714 1.23 −1.09 −1.17 1.25 −1.44 1.37 1.51
CD8A 13.23 0.0412 0.1604 0.8832 0.2939 0.7299 0.4394 0.8534 1.30 1.24 1.56 −1.44 −1.24 1.05 1.44
ADAM17 12.71 0.1919 0.8616 0.6441 0.1633 0.2687 0.7874 0.7724 1.15 1.02 1.29 1.49 −1.01 1.68 1.37
PTPRC 12.65 0.0279 0.7490 0.7072 0.5853 0.4100 0.2291 0.5759 1.24 1.04 1.20 −1.15 −1.53 1.41 1.53
PTGS2 12.55 0.0630 0.9846 0.6788 0.0812 0.9289 0.1552 0.9724 1.28 −1.00 1.15 −1.87 −1.79 1.17 1.18
IL1RN 12.41 0.3848 0.0842 0.1495 0.1451 0.6460 0.1061 0.8547 −1.13 −1.33 −1.03 −1.73 −1.38 1.48 2.18
ICAM1 11.99 0.2755 0.2793 0.7173 0.4375 0.4882 0.2839 0.3328 1.13 −1.16 1.06 −1.27 −1.68 1.31 2.10
APAF1 11.91 0.0852 0.8732 0.8466 0.8508 0.4636 0.0957 0.6159 1.20 −1.02 1.13 −1.05 −1.38 1.96 1.06
MNDA 11.64 0.0662 0.9441 0.3044 0.5092 0.6863 0.3526 0.3483 1.24 −1.01 −1.03 −1.23 −1.46 1.28 2.29
IL18BP 10.94 0.1220 0.0913 0.1308 0.6556 0.3362 0.4393 0.4857 1.14 1.18 1.06 1.11 −1.20 1.45 1.62
SERPING1 10.70 0.4339 0.2313 0.9868 0.5224 0.9825 0.7008 0.2993 −1.21 −1.41 −1.69 −1.52 −1.49 −1.03 5.36
IL1R1 10.49 0.1039 0.7632 0.9654 0.7602 0.3975 0.2078 0.9550 1.34 −1.07 1.28 −1.16 −2.00 2.25 1.40
IL1B 10.09 0.6746 0.3584 0.4113 0.3254 0.7338 0.1561 0.9919 −1.07 −1.19 1.01 −1.52 −1.84 1.68 1.40
TLR2 9.82 0.2787 0.6278 0.5153 0.7197 0.1332 0.2841 0.8863 1.15 1.08 1.06 1.14 −1.77 2.05 1.16
TNFSF5 9.48 0.3867 0.3648 0.1478 0.0599 0.4390 0.3545 0.6951 1.12 1.16 −1.12 −2.01 −1.39 −1.19 −1.18
IFI16 6.46 0.5860 0.6442 0.5085 0.2437 0.8924 0.4439 0.9634 1.09 1.09 −1.02 −1.62 −1.74 1.00 −1.02
CD19 5.24 0.1827 0.4304 0.1925 0.3513 0.1437 0.4404 0.5098 1.23 1.16 −1.03 1.48 −1.51 −1.11 −1.25
  1. Values were computed only for white and Hispanic subjects for whom sex and age were recorded (n = 68). Unadjusted Pvalues are shown for each effect, including interaction terms, and underlined (together with corresponding fold changes) when < 0.05. Fold changes for sex and ethnicity effects are computed by raising 2 to the power of the corresponding ΔCT effect terms; for age effects, they are computed by multiplying the corresponding slope effect by the range of ages in the sample (69 − 23) and then exponentiating. HF indicates Hispanic female; HM, Hispanic male; WF, white female; WM, white male.
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Molecular Medicine

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