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Table 1 Matriptase expression in human cancer

From: Matriptase: Potent Proteolysis on the Cell Surface

Study

Sample No.

Method

Expression

Correlation with Grade or Stage

Correlation with Survival

Breast cancer

     

Kang et al., 2003 (41)

320

IHC

229 (72%) samples low expressing 91 (28%) samples high expressing

N/A

High matriptase expression predictive of poor survival

Parr et al., 2004 (40)

120

qRT-PCR

Matriptase was not significantly increased in tumors compared with normal breast tissue

No correlation

No correlation

Cervical cancer

     

Santin et al., 2003 (39)

19

IHC/RT-PCR

0/8 (0%) in normal squamous epithelia

6/6 (100%) in SCC 2/5 (40%) in adenocarcinomas

N/A

N/A

Lee et al., 2005 (25)

89

IHC/LCM/RT-PCR

0/10 (0%) in normal squamous epithelia

4/19 (21%) in LSIL

12/20 (60%) in HSIL 38/40 (95%) in invasive SSC

Frequency of matriptase detection increased with histopathological grade

N/A

Ovarian cancer

     

Tanimoto et al., 2005 (38)

96

IHC/sqRT-PCR

0/7 (0%) of normal ovarian tissue 50/89 (56%) of ovarian carcinomas

Matriptase more frequently expressed in stage 1 tumors compared with advanced stage tumors

Positive correlation between matriptase expression and overall survival

Oberst et al., 2002 (43)

54

IHC

39/54 (72%) of ovarian carcinomas expressed matriptase

Matriptase more frequently expressed in stage 1 tumors compared with advanced stage tumors

N/A

Prostate cancer

     

Riddick et al., 2005 (35)

67

qRT-PCR

Significant increase (2–3 fold) of matriptase expression in malignant vs. nonmalignant samples

Significant positive correlation with Gleason score

N/A

Gastrointestinal cancer

     

Zeng et al., 2005 (36)

77

qRT-PCR

Significant downregulation of matriptase in gastric and colorectal cancer compared with adjacent normal tissue

No significant correlation with stage or lymph node metastasis status

N/A

  1. IHC, immunohistochemistry; LCM, laser capture microscopy; RT-PCR, reverse-transcriptase polymerase chain reaction; qRT-PCR, quantitative RT-PCR; sqRT-PCR, semiquantitative RT-PCR; LSIL, low-grade squamous intraepithelial lesions; HSIL, high-grade squamous intraepithelial lesions.