Table 1 :Summary of currently known cells which exhibit Zn2+ -dependent Ca2+ signaling via the putative ZnR pathway.
From: The Zinc Sensing Receptor, a Link Between Zinc and Cell Signaling
| Zn2+ -dependent Ca2+ rise, via the IP3 pathway | Signaling pathway activated by extracellular Zn2+ | Physiological outcome | Ref | |
|---|---|---|---|---|
| HT29 colonocytes | + + + | MAPK; PI3K; CaMK; clusterin | NHE1 upregulation | (22,29) |
| PC-3 androgen independent prostate cancer | + + | MAPK; PI3K; PKC | Cell proliferation and survival | In prep. |
| HaCaT, (Normal human) keratinocytes | + + | MAPK; PI3K | Enhanced wound healing | (22) |
| 3T3 and human Fibroblasts | No response | None | — | |
| Neurons — acute slice | + + | MAPK | Unknown | In prep. |
| Glia cell — primary | No response | None | — | |
| C6 glioma cells | No response | None | — | |
| Pancreatic β cells | + + | Unknown | Unknown | |
| INS pancreatic α cells | No response | None | — | |
| HSY salivary gland | + + + | Unknown | Paracrine activity; ATP secretion | (24) |