Table 1 :Summary of currently known cells which exhibit Zn2+ -dependent Ca2+ signaling via the putative ZnR pathway.
From: The Zinc Sensing Receptor, a Link Between Zinc and Cell Signaling
| Â | Zn2+ -dependent Ca2+ rise, via the IP3 pathway | Signaling pathway activated by extracellular Zn2+ | Physiological outcome | Ref |
|---|---|---|---|---|
HT29 colonocytes | + + + | MAPK; PI3K; CaMK; clusterin | NHE1 upregulation | |
PC-3 androgen independent prostate cancer | + + | MAPK; PI3K; PKC | Cell proliferation and survival | In prep. |
HaCaT, (Normal human) keratinocytes | + + | MAPK; PI3K | Enhanced wound healing | (22) |
3T3 and human Fibroblasts | No response | None | — |  |
Neurons — acute slice | + + | MAPK | Unknown | In prep. |
Glia cell — primary | No response | None | — |  |
C6 glioma cells | No response | None | — |  |
Pancreatic β cells | + + | Unknown | Unknown |  |
INS pancreatic α cells | No response | None | — |  |
HSY salivary gland | + + + | Unknown | Paracrine activity; ATP secretion | (24) |