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Table 1 Effect of kainate treatment on motoneuron viability in the absence or presence of EPO derivatives.

From: Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo

Motoneuron survival (% of controls)

(No. replicates)

Without cytokine

With cytokine

ASIALO-EPO (12)

58 ± 11

91 ± 12a

CEPO (15)

42 ± 12

67 ± 19b

  1. Viability of SMI 32-positive motoneurons in mixed neuron/glia cultures after 48-h incubation with kainate (5 µM). When present, cytokines (100 ng/mL) were added to motoneuron cultures 3 days before treatment and re-added with the glutamate agonist. Data represent mean ± SD. For both ASIALO-EPO and CEPO, fint P < 0.001. aP < 0.001, bP > 0.01, different from control motoneurons, 2-way ANOVA and Tukey’s test.
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Molecular Medicine

ISSN: 1528-3658