Figure 1

Determination of the oxidative imbalance in patients with stable angina pectoris and acute ST-segment elevation myocardial infarction. (A) Total plasma hydrogen peroxide concentration measurements. (B) Serum 8OHdG level measurements. Results are expressed as mean (represented by squares) ± SEM (represented by boxes) and ± SD (represented by bars). Lane 1 indicates peroxide levels in stable angina patients; lanes 2–5 show peroxide concentration in patients with acute myocardial infarction before coronarography (lane 2), just after the successful primary PCI (lane 3), 24 ± 4 h after reperfusion of the ischemic myocardium (lane 4), and 96 ± 4 h after PCI (lane 5). Primary PCI itself did not affect total peroxide levels; gradual increase of hydrogen peroxide concentration was observed at 24- and 96-h time points after myocardial infarction. In contrast, serum 8OHdG levels showed a significant, rapid increase after the primary PCI, and were normalized by 96 h. *P < 0.05, **P < 0.005; NS, nonsignificant.