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Table 1 Baseline characteristics

From: Hepcidin Expression in the Liver: Relatively Low Level in Patients with Chronic Hepatitis C

   

HCV−HBV− (n = 42)

P

 

HCV+

HBV+

Non-iron overload

Iron overload

HCV+ vs. HBV+

HCV+ vs. HCV−HBV− non-iron overload

HCV+ vs. HCV−HBV− iron overload

n

56

34

24

18

   

Age, y

56.0 ± 13.7

50.4 ± 15.2

55.0 ± 17.5

53.4 ± 16.9

NS

NS

NS

Sex, M/F

33/23

23/11

9/15

8/10

NS

NS

NS

ALT, IU/L

76.9 ± 67.7

104 ± 131

63.4 ± 67.7

149 ± 157

NS

NS

0.0472

AST, IU/L

80.6 ± 85.0

110 ± 141

81.5 ± 126

183 ± 238

NS

NS

NS

Bilirubin, mg/dL

1.50 ± 3.60

1.26 ± 1.59

1.64 ± 3.88

5.90 ± 11.7

NS

NS

NS

RBC, × 104/mm3

418 ± 71

430 ± 56

401 ± 54

407 ± 77

NS

NS

NS

Hemoglobin, g/L

133 ± 19

137 ± 17

118 ±19

131 ± 21

NS

0.0014

NS

Hematocrit, %

40.0 ± 5.2

41.6 ± 4.9

37.7 ± 5.3

38.8 ± 6.6

NS

NS

NS

Serum iron, µg/dL

131 ± 48

123 ± 50

60 ± 37

99 ± 53

NS

<0.0001

NS

Transferrin saturation, %

39.3 ± 15.7

40.7 ± 17.0

19.5 ± 13.5

38.7 ± 22.8

NS

<0.0001

NS

Serum ferritin, ng/mL

244 ± 162

140 ± 101

91 ± 76

585 ± 784

NS

<0.0001

NS

Liver histology

       

Inflammatory activity, 0/1/2/3a

1/23/28/4

1/12/14/7

9/13/2/0

2/13/1/2

NS

<0.0001

0.0052

Fibrosis staging, 0/1/2/3/4b

2/19/14/10/11

0/6/10/9/9

9/10/4/1/0

6/9/0/1/2

NS

0.0002

0.0016

TISc

7.36 ± 5.35

4.41 ± 4.49

1.21 ± 2.00

7.72 ± 8.50

0.0163

<0.0001

NS

  1. Data are means ± SD. ALT, alanine aminotransferase; AST, apsartate aminotransferase; NS, not significant; RBC, red blood cell count. aIntensity of necroinflammatory lesions: 0, no histological activity; 1, mild activity; 2, moderate activity; 3, severe activity. b0, no fibrosis; 1, portal fibrosis without septa; 2, portal fibrosis with few septa; 3, numerous septa without cirrhosis; 4, cirrhosis. cTotal iron score proposed by Deugnier et al. (23).