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Table 3 Effect of HF diet feeding on serum lipid profile and ghrelin and adipokine serum levels.

From: Paraoxonase 1 Response to a High-Fat Diet: Gender Differences in the Factors Involved

 

Male

Female

 
 

Control

HF fed

Control

HF fed

ANOVA

Triacylglycerols (mM)

2.48 ± 0.16

2.08 ± 0.15

2.90 ±0.41

2.05 ±0.27

D

Free fatty acids (mM)

0.91 ± 0.04

0.67 ± 0.04a

0.93 ±0.08

0.95 ± 0.05b

G,G*D

Total cholesterol (mM)

1.74 ± 0.12

1.63 ± 0.15

1.50 ±0.10

1.26 ± 0.14

G

HDL-cholesterol (mM)

0.21 ± 0.01

0.23 ± 0.01

0.25 ±0.03

0.20 ±0.02

NS

LDL-cholesterol (mM)

0.63 ± 0.23

0.59 ± 0.08

0.71 ±0.07

0.53 ± 0.06

NS

LDL/HDL ratio

2.90 ± 0.93

2.51 ± 0.24

2.63 ±0.26

2.72 ±0.55

NS

Glucose (mM)

8.20 ± 0.27

8.10 ± 0.60

6.62 ±0.28

7.00 ±0.32

G

Insulin (µg/L)

0.28 ± 0.03

0.42 ± 0.06

0.23 ±0.02

0.37 ± 0.10

D

HOMA-IR

2.92 ± 0.27

4.06 ± 0.45

1.98 ± 0.23

3.40 ± 1.02

D

Ghrelin (ng/mL)

0.76 ± 0.24

0.30 ± 0.10

0.48 ±0.15

0.29 ±0.07

D

Adiponectin (µg/mL)

8.17 ± 0.82

12.6 ± 1.51a

9.23 ± 1.02

8.32 ±0.87b

G*D

Leptin (ng/mL)

0.98 ± 0.22

1.25 ± 0.19

0.77 ±0.17

0.52 ±0.11

G

[TBL]PAI-1 (AU)

100 ± 14

106 ± 9

135 ± 12

120 ± 9

NS

  1. aHF vs. control.
  2. bfemale vs. male.
  3. Values are expressed as the mean ± S.E.M. of seven animals per group.
  4. HOMA-IR was calculated as [blood fasting glucose (mmol/L) × blood fasting insulin (µU/mL)]/22.5.
  5. PAI-1 levels were measured by immunoblot.
  6. ANOVA (P < 0.05).
  7. G, gender effect.
  8. D, diet effect.
  9. G*D, interactive effect.
  10. NS, non significant.
  11. t-Test (P < 0.05).