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Table 1 Selected genes differentially expressed in DM are grouped according to functional classification. The average fold change in DM compared with healthy controls is included (“Avg FC”), in addition to the p-value from unpaired t-test.

From: An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity

  Entrez Gene Gene Title Gene Symbol Avg FC p-value
Immune-related 27178 interleukin 1 family, member 7 (zeta) IL1F7 −2.1 4.5×10−5
  54756 interleukin 17 receptor D IL17RD −2.1 4.1×10−4
  50604 interleukin 20 IL20 −2.1 2.7×10−4
  282618 interleukin 29 (interferon, lambda 1) IL29 −1.8 4.4×10−4
  3656 interleukin-1 receptor-associated kinase 2 IRAK2 −4.7 5.9×10−6
  2833 chemokine (C-X-C motif) receptor 3 CXCR3 −2.5 4.2×10−4
  975 CD81 antigen CD81 −3.8 7.8×10−6
  6279 S100 calcium binding protein A8 (calgranulin A) S100A8 3.5 2.5×10−4
  10673 TNF ligand superfamily, member 13b (BAFF) TNFSF13B 2.9 1.4×10−4
  2534 FYN oncogene related to SRC, FGR, YES FYN −1.6 2.4×10−4
  23308 inducible T-cell co-stimulator ligand ICOSLG −1.9 2.4×10−4
  4776 nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 3.0 4.9×10−4
  79109 MAP kinase associated protein 1 MAPKAP1 −2.4 9.7×10−7
  6885 MAP kinase kinase kinase 7 MAP3K7 −1.6 1.8×10−4
  4293 MAP kinase kinase kinase 9 MAP3K9 −1.9 1.8×10−5
  3811 killer cell Ig-like receptor, 3 domains, long 1 KIR3DL1 −2.8 3.5×10−5
  3803 killer cell Ig-like receptor, 2 domains, long 2 KIR2DL2 −4.6 6.1×10−8
  3804 killer cell Ig-like receptor, 2 domains, long 3 KIR2DL3 −2.1 4.6×10−6
  57292 killer cell Ig-like receptor, 2 domains, long 5A KIR2DL5A −3.4 2.0×10−7
  3809 killer cell Ig-like receptor, 2 domains, short 4 KIR2DS4 −4.4 3.6×10−4
  3810 killer cell Ig-like receptor, 2 domains, short 5 KIR2DS5 −3.2 7.9×10−6
  10219 killer cell lectin-like receptor subfamily G 1 KLRG1 −1.6 2.6×10−5
Autoantigens 120364 heterogeneous nuclear ribonucleoprotein A1 HNRPA1 −2.2 8.8×10−6
  3183 heterogeneous nuclear ribonucleoprotein C (C1/C2) HNRPC −1.9 1.8×10−4
  9987 heterogeneous nuclear ribonucleoprotein D-like HNRPDL −2.0 7.5×10−5
  3192 heterogeneous nuclear ribonucleoprotein U HNRPU −1.6 2.4×10−4
  8331 histone 1, H2aj HIST1H2AJ 2.1 3.9×10−4
  8337 histone 2, H2aa HIST2H2AA 2.3 1.3×10−4
  10534 Sjogren’s syndrome/scleroderma autoantigen 1 SSSCA1 2.0 5.2×10−5
  6672 nuclear antigen Sp100 SP100 1.6 3.7×10−4
Muscle-related 23026 myosin heavy chain Myr 8 MYR8 −2.5 7.4×10−5
  29116 myosin regulatory light chain interacting protein MYLIP −2.0 4.4×10−5
  10627 myosin regulatory light chain MRCL3 MRCL3 1.7 4.6×10−4
  55930 myosin VC MYO5C −1.6 4.7×10−4
  8082 sarcospan (Kras oncogene-associated gene) SSPN −1.8 3.4×10−4
  81493 syncoilin, intermediate filament 1 SYNC1 −2.0 3.8×10−4
  1285 collagen, type IV, α 3 (Goodpasture antigen) COL4A3 −3.0 2.2×10−4
  1287 collagen, type IV, α 5 (Alport syndrome) COL4A5 −2.4 3.2×10−4
  1288 collagen, type IV, α 6 COL4A6 −3.2 1.8×10−5
  1291 collagen, type VI, α 1 COL6A1 −2.8 1.4×10−5
  1674 desmin DES 4.2 2.7×10−4
Mitochondrial/oxidative 1329 cytochrome c oxidase subunit Vb COX5B 5.7 1.3×10−4
  1337 cytochrome c oxidase subunit VIa polypeptide 1 COX6A1 1.9 6.8×10−5
  1353 COX11 homolog COX11 −2.1 4.9×10−4
  517 ATP synthase, mitochondrial F0 complex, c 2 ATP5G2 −4.8 2.8×10−5
  93974 ATPase inhibitory factor 1 ATPIF1 1.6 3.0×10−5
  4695 NADH dehydrogenase 1 α 2 NDUFA2 1.5 3.1×10−4
  4710 NADH dehydrogenase 1 β 4 NDUFB4 1.5 1.6×10−4
  5832 aldehyde dehydrogenase 18 family, member A1 ALDH18A1 −1.8 1.1×10−5
  221 aldehyde dehydrogenase 3 family, member B1 ALDH3B1 −3.4 3.6×10−5
  1544 cytochrome P450, family 1 A2 CYP1A2 −1.7 1.8×10−4
  1584 cytochrome P450, family 11 B1 CYP11B1 −2.7 3.4×10−5
  1559 cytochrome P450, family 2 C9 CYP2C9 −3.0 1.3×10−5
  1579 cytochrome P450, family 4 A11 CYP4A11 −2.8 1.3×10−4
  1595 cytochrome P450, family 51 A1 CYP51A1 −1.6 2.7×10−4
  1582 cytochrome P450, family 8 B1 CYP8B1 −2.1 1.5×10−4
  2878 glutathione peroxidase 3 (plasma) GPX3 −2.0 1.6×10−5
  25824 peroxiredoxin 5 PRDX5 1.7 2.4×10−4
  7295 thioredoxin TXN 2.8 1.1×10−6
  65003 mitochondrial ribosomal protein L11 MRPL11 1.6 2.0×10−4
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Molecular Medicine

ISSN: 1528-3658