Table 1 Selected genes differentially expressed in DM are grouped according to functional classification. The average fold change in DM compared with healthy controls is included (“Avg FC”), in addition to the p-value from unpaired t-test.
Entrez Gene | Gene Title | Gene Symbol | Avg FC | p-value | |
|---|---|---|---|---|---|
Immune-related | 27178 | interleukin 1 family, member 7 (zeta) | IL1F7 | −2.1 | 4.5×10−5 |
54756 | interleukin 17 receptor D | IL17RD | −2.1 | 4.1×10−4 | |
50604 | interleukin 20 | IL20 | −2.1 | 2.7×10−4 | |
282618 | interleukin 29 (interferon, lambda 1) | IL29 | −1.8 | 4.4×10−4 | |
3656 | interleukin-1 receptor-associated kinase 2 | IRAK2 | −4.7 | 5.9×10−6 | |
2833 | chemokine (C-X-C motif) receptor 3 | CXCR3 | −2.5 | 4.2×10−4 | |
975 | CD81 antigen | CD81 | −3.8 | 7.8×10−6 | |
6279 | S100 calcium binding protein A8 (calgranulin A) | S100A8 | 3.5 | 2.5×10−4 | |
10673 | TNF ligand superfamily, member 13b (BAFF) | TNFSF13B | 2.9 | 1.4×10−4 | |
2534 | FYN oncogene related to SRC, FGR, YES | FYN | −1.6 | 2.4×10−4 | |
23308 | inducible T-cell co-stimulator ligand | ICOSLG | −1.9 | 2.4×10−4 | |
4776 | nuclear factor of activated T-cells, cytoplasmic 4 | NFATC4 | 3.0 | 4.9×10−4 | |
79109 | MAP kinase associated protein 1 | MAPKAP1 | −2.4 | 9.7×10−7 | |
6885 | MAP kinase kinase kinase 7 | MAP3K7 | −1.6 | 1.8×10−4 | |
4293 | MAP kinase kinase kinase 9 | MAP3K9 | −1.9 | 1.8×10−5 | |
3811 | killer cell Ig-like receptor, 3 domains, long 1 | KIR3DL1 | −2.8 | 3.5×10−5 | |
3803 | killer cell Ig-like receptor, 2 domains, long 2 | KIR2DL2 | −4.6 | 6.1×10−8 | |
3804 | killer cell Ig-like receptor, 2 domains, long 3 | KIR2DL3 | −2.1 | 4.6×10−6 | |
57292 | killer cell Ig-like receptor, 2 domains, long 5A | KIR2DL5A | −3.4 | 2.0×10−7 | |
3809 | killer cell Ig-like receptor, 2 domains, short 4 | KIR2DS4 | −4.4 | 3.6×10−4 | |
3810 | killer cell Ig-like receptor, 2 domains, short 5 | KIR2DS5 | −3.2 | 7.9×10−6 | |
10219 | killer cell lectin-like receptor subfamily G 1 | KLRG1 | −1.6 | 2.6×10−5 | |
Autoantigens | 120364 | heterogeneous nuclear ribonucleoprotein A1 | HNRPA1 | −2.2 | 8.8×10−6 |
3183 | heterogeneous nuclear ribonucleoprotein C (C1/C2) | HNRPC | −1.9 | 1.8×10−4 | |
9987 | heterogeneous nuclear ribonucleoprotein D-like | HNRPDL | −2.0 | 7.5×10−5 | |
3192 | heterogeneous nuclear ribonucleoprotein U | HNRPU | −1.6 | 2.4×10−4 | |
8331 | histone 1, H2aj | HIST1H2AJ | 2.1 | 3.9×10−4 | |
8337 | histone 2, H2aa | HIST2H2AA | 2.3 | 1.3×10−4 | |
10534 | Sjogren’s syndrome/scleroderma autoantigen 1 | SSSCA1 | 2.0 | 5.2×10−5 | |
6672 | nuclear antigen Sp100 | SP100 | 1.6 | 3.7×10−4 | |
Muscle-related | 23026 | myosin heavy chain Myr 8 | MYR8 | −2.5 | 7.4×10−5 |
29116 | myosin regulatory light chain interacting protein | MYLIP | −2.0 | 4.4×10−5 | |
10627 | myosin regulatory light chain MRCL3 | MRCL3 | 1.7 | 4.6×10−4 | |
55930 | myosin VC | MYO5C | −1.6 | 4.7×10−4 | |
8082 | sarcospan (Kras oncogene-associated gene) | SSPN | −1.8 | 3.4×10−4 | |
81493 | syncoilin, intermediate filament 1 | SYNC1 | −2.0 | 3.8×10−4 | |
1285 | collagen, type IV, α 3 (Goodpasture antigen) | COL4A3 | −3.0 | 2.2×10−4 | |
1287 | collagen, type IV, α 5 (Alport syndrome) | COL4A5 | −2.4 | 3.2×10−4 | |
1288 | collagen, type IV, α 6 | COL4A6 | −3.2 | 1.8×10−5 | |
1291 | collagen, type VI, α 1 | COL6A1 | −2.8 | 1.4×10−5 | |
1674 | desmin | DES | 4.2 | 2.7×10−4 | |
Mitochondrial/oxidative | 1329 | cytochrome c oxidase subunit Vb | COX5B | 5.7 | 1.3×10−4 |
1337 | cytochrome c oxidase subunit VIa polypeptide 1 | COX6A1 | 1.9 | 6.8×10−5 | |
1353 | COX11 homolog | COX11 | −2.1 | 4.9×10−4 | |
517 | ATP synthase, mitochondrial F0 complex, c 2 | ATP5G2 | −4.8 | 2.8×10−5 | |
93974 | ATPase inhibitory factor 1 | ATPIF1 | 1.6 | 3.0×10−5 | |
4695 | NADH dehydrogenase 1 α 2 | NDUFA2 | 1.5 | 3.1×10−4 | |
4710 | NADH dehydrogenase 1 β 4 | NDUFB4 | 1.5 | 1.6×10−4 | |
5832 | aldehyde dehydrogenase 18 family, member A1 | ALDH18A1 | −1.8 | 1.1×10−5 | |
221 | aldehyde dehydrogenase 3 family, member B1 | ALDH3B1 | −3.4 | 3.6×10−5 | |
1544 | cytochrome P450, family 1 A2 | CYP1A2 | −1.7 | 1.8×10−4 | |
1584 | cytochrome P450, family 11 B1 | CYP11B1 | −2.7 | 3.4×10−5 | |
1559 | cytochrome P450, family 2 C9 | CYP2C9 | −3.0 | 1.3×10−5 | |
1579 | cytochrome P450, family 4 A11 | CYP4A11 | −2.8 | 1.3×10−4 | |
1595 | cytochrome P450, family 51 A1 | CYP51A1 | −1.6 | 2.7×10−4 | |
1582 | cytochrome P450, family 8 B1 | CYP8B1 | −2.1 | 1.5×10−4 | |
2878 | glutathione peroxidase 3 (plasma) | GPX3 | −2.0 | 1.6×10−5 | |
25824 | peroxiredoxin 5 | PRDX5 | 1.7 | 2.4×10−4 | |
7295 | thioredoxin | TXN | 2.8 | 1.1×10−6 | |
65003 | mitochondrial ribosomal protein L11 | MRPL11 | 1.6 | 2.0×10−4 |