Evolution of cerebral ischemia in rats treated with vehicle or reparixin after permanent ischemia. Reparixin (15 mg/kg) was given 1 h after MCAO followed by three 15 mg/kg s.c. doses at 2 h intervals. A) Representative Tr(D) images of a coronal brain section taken 2, 24, and 48 h after the induction of ischemia in rats treated with vehicle (top) or reparixin (bottom). B) Infarct volume measured at different times in the Tr(D) images of vehicle (n = 8) or reparixin-treated rats (n = 8). *The evolution of the lesions with time, was significantly different from vehicle and drug treated groups, considering the whole time course of each group (P < 0.05).