
Total infarct

Cortex

Striatum


Experiment 1
   
Saline (n = 6)

273 ± 24

181 ± 24

89 ± 9

Reparixin (n = 5)

68 ±8 **

12 ± 4 **

56 ± 9 *

Experiment 2
   
Saline (n = 8)

271 ± 25

193 ± 19

78 ± 8

Reparixin (n = 7)

143 ± 23 *

64 ± 18 **

79 ± 8

 Results from 2 independent experiments are given. Data are expressed as the infarct volume in mm^{3} and are the mean ± S.E; the number of rats per group is indicated in parenthesis. Experiment 1: reparixin was administered on the first day at 15 mg/kg i.v. starting 2 h after reperfusion followed by two 15 mg/kg s.c. doses at 2 h intervals. Experiment 2: reparixin was administered on the first day at 15 mg/kg i.v. starting at the time of ischemia followed by four 15 mg/kg s.c. doses at 2 h intervals. Infarct volumes are determined 24 h after MCAO. * P < 0.05 and ** P < 0.01 vs. saline (Student ttest).