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Table 1 Effect of reparixin on cortical vs. subcortical damage 24 h after transient MCAO

From: The Interleukin-8 (IL-8/CXCL8) Receptor Inhibitor Reparixin Improves Neurological Deficits and Reduces Long-term Inflammation in Permanent and Transient Cerebral Ischemia in Rats

  Total infarct Cortex Striatum
Experiment 1    
  Saline (n = 6) 273 ± 24 181 ± 24 89 ± 9
  Reparixin (n = 5) 68 ±8 ** 12 ± 4 ** 56 ± 9 *
Experiment 2    
  Saline (n = 8) 271 ± 25 193 ± 19 78 ± 8
  Reparixin (n = 7) 143 ± 23 * 64 ± 18 ** 79 ± 8
  1. Results from 2 independent experiments are given. Data are expressed as the infarct volume in mm3 and are the mean ± S.E; the number of rats per group is indicated in parenthesis. Experiment 1: reparixin was administered on the first day at 15 mg/kg i.v. starting 2 h after reperfusion followed by two 15 mg/kg s.c. doses at 2 h intervals. Experiment 2: reparixin was administered on the first day at 15 mg/kg i.v. starting at the time of ischemia followed by four 15 mg/kg s.c. doses at 2 h intervals. Infarct volumes are determined 24 h after MCAO. * P < 0.05 and ** P < 0.01 vs. saline (Student t-test).