Table 1 Nomenclature and Known Function of LIV-1 Family Members.
From: The Emerging Role of the LIV-1 Subfamily of Zinc Transporters in Breast Cancer
Human | Â | Â | Â | Â | Â | Â | Â | Â |
|---|---|---|---|---|---|---|---|---|
gene name | Protein name | Other names | Cell location | Tissue distribution | Transport function | Disease link | Chromosome | Accession number |
SLC39A4 | ZIP4 | LZT-Hs5 | PM | Small intestine, stomach, colon, cecum, kidney | Zinc uptake | 8q24.3 | NM_017767 | |
SLC39A5 | ZIP5 | LZT-Hs7 | Basolateral surface of polarized cells | Kidney, liver, spleen, colon, stomach, pancreas | Zinc removal | Â | 12q13.13 | NM_173596 |
SLC39A6 | LIV-1, ZIP6 | LZT-Hs3 | PM | Widespread | Zinc influx | 18q12.1 | NM_012319 | |
SLC39A7 | HKE4, ZIP7 | LZT-Hs1 | ER and Golgi | widespread | Zinc and manganese bidirectional? (20) | Tamoxifen resistance in breast cancer | 6p21.3 | NM_006979 |
SLC39A8 | BIGM103, ZIP8 | LZT-Hs6 | Vesicles | Widespread | Cadmium influx (11), Zinc influx | Faslodex resistance in breast cancer | 4q22-q24 | NM_022154 |
SLC39A10 | ZIP10 | LZT-Hs2 | PM | Widespread | Zinc influx | Â | 2q33.1 | NM_020342 |
SLC39A12 | ZIP12 | LZT-Hs8 | Â | Brain, lung, testis, retina | Â | Asthma (32) | 10p12.33 | NM_152725 |
SLC39A13 | ZIP13 | LZT-Hs9 | Â | Widespread | Â | Â | 11p11.12 | NM_152264 |
SLC39A14 | ZIP14 | LZT-Hs4 | PM | Widespread | Zinc influx, non-transferrin-bound iron uptake (12) | 8p21.2 | NM_015359 |