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Table 2 Summary of LIV-1 Family Expression Response to Treatments or Antihormone Resistance

From: The Emerging Role of the LIV-1 Subfamily of Zinc Transporters in Breast Cancer

Cells

ZIP4

ZIP5

LIV-1

HKE4

ZIP8

ZIP10

ZIP12

ZIP13

ZIP14

MCF-7 + E2

ND

—

Up

Up

Down

   

Up

MCF-7 + TAM

ND

—

—

—

—

—

—

—

Down

MCF-7 + FAS

ND

—

Down

—

—

—

—

—

Down

Tamoxifen-resistant cells

ND

—

—

Up

—

—

—

—

—

Fulvestrant-resistant cells

ND

—

—

Up

Up

—

—

—

—

  1. ND, not determined; —, no change.