TY - JOUR AU - Weiss, J. H. AU - Sensi, S. L. AU - Koh, J. Y. PY - 2000 DA - 2000// TI - Zn(2+): a novel ionic mediator of neural injury in brain disease JO - Trends Pharmacol. Sci. VL - 21 UR - https://doi.org/10.1016/S0165-6147(00)01541-8 DO - 10.1016/S0165-6147(00)01541-8 ID - Weiss2000 ER - TY - JOUR AU - Qian, J. AU - Noebels, J. L. PY - 2006 DA - 2006// TI - Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse JO - J. Neurosci. VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.0475-06.2006 DO - 10.1523/JNEUROSCI.0475-06.2006 ID - Qian2006 ER - TY - JOUR AU - Qian, J. AU - Noebels, J. L. PY - 2005 DA - 2005// TI - Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fiber synapse JO - J. Physiol. VL - 566 UR - https://doi.org/10.1113/jphysiol.2005.089276 DO - 10.1113/jphysiol.2005.089276 ID - Qian2005 ER - TY - JOUR AU - Frederickson, C. J. AU - Koh, J. Y. AU - Bush, A. I. PY - 2005 DA - 2005// TI - The neurobiology of zinc in health and disease JO - Nat. Rev. Neurosci. VL - 6 UR - https://doi.org/10.1038/nrn1671 DO - 10.1038/nrn1671 ID - Frederickson2005 ER - TY - JOUR AU - Sensi, S. L. AU - Jeng, J. M. PY - 2004 DA - 2004// TI - Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury JO - Curr. Mol. Med. VL - 4 UR - https://doi.org/10.2174/1566524043479211 DO - 10.2174/1566524043479211 ID - Sensi2004 ER - TY - JOUR AU - Frederickson, C. J. PY - 1989 DA - 1989// TI - Neurobiology of zinc and zinc-containing neurons JO - Int. Rev. Neurobiol VL - 31 UR - https://doi.org/10.1016/S0074-7742(08)60279-2 DO - 10.1016/S0074-7742(08)60279-2 ID - Frederickson1989 ER - TY - JOUR AU - Suh, S. W. PY - 1999 DA - 1999// TI - Detection of pathological zinc accumulation in neurons: methods for autopsy, biopsy, and cultured tissue JO - J. Histochem. Cytochem. VL - 47 UR - https://doi.org/10.1177/002215549904700715 DO - 10.1177/002215549904700715 ID - Suh1999 ER - TY - JOUR AU - Lee, J. Y. AU - Cole, T. B. AU - Palmiter, R. D. AU - Koh, J. Y. PY - 2000 DA - 2000// TI - Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin JO - J. Neurosci. VL - 20 UR - https://doi.org/10.1523/JNEUROSCI.20-11-j0003.2000 DO - 10.1523/JNEUROSCI.20-11-j0003.2000 ID - Lee2000 ER - TY - JOUR AU - Frazzini, V. AU - Rockabrand, E. AU - Mocchegiani, E. AU - Sensi, S. L. PY - 2006 DA - 2006// TI - Oxidative stress and brain aging: is zinc the link? JO - Biogerontology VL - 7 UR - https://doi.org/10.1007/s10522-006-9045-7 DO - 10.1007/s10522-006-9045-7 ID - Frazzini2006 ER - TY - JOUR AU - Outten, C. E. AU - O’Halloran, T. V. PY - 2001 DA - 2001// TI - Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis JO - Science VL - 292 UR - https://doi.org/10.1126/science.1060331 DO - 10.1126/science.1060331 ID - Outten2001 ER - TY - JOUR AU - Krezel, A. AU - Maret, W. PY - 2006 DA - 2006// TI - Zinc-buffering capacity of a eukaryotic cell at physiological pZn JO - J. Biol. Inorg. Chem. VL - 11 UR - https://doi.org/10.1007/s00775-006-0150-5 DO - 10.1007/s00775-006-0150-5 ID - Krezel2006 ER - TY - JOUR AU - Palmiter, R. D. PY - 1987 DA - 1987// TI - Molecular biology of metallothionein gene expression JO - Experientia. Suppl. VL - 52 UR - https://doi.org/10.1007/978-3-0348-6784-9_4 DO - 10.1007/978-3-0348-6784-9_4 ID - Palmiter1987 ER - TY - JOUR AU - Masters, B. A. PY - 1994 DA - 1994// TI - Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles JO - J. Neurosci. VL - 14 UR - https://doi.org/10.1523/JNEUROSCI.14-10-05844.1994 DO - 10.1523/JNEUROSCI.14-10-05844.1994 ID - Masters1994 ER - TY - JOUR AU - Quaife, C. J. AU - Findley, S. D. AU - Erickson, J. C. PY - 1994 DA - 1994// TI - Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia JO - Biochemistry VL - 33 UR - https://doi.org/10.1021/bi00189a029 DO - 10.1021/bi00189a029 ID - Quaife1994 ER - TY - JOUR AU - Maret, W. PY - 2000 DA - 2000// TI - The function of zinc metallothionein: a link between cellular zinc and redox state JO - J. Nutr. VL - 130 UR - https://doi.org/10.1093/jn/130.5.1455S DO - 10.1093/jn/130.5.1455S ID - Maret2000 ER - TY - JOUR AU - Maret, W. AU - Vallee, B. L. PY - 1998 DA - 1998// TI - Thiolate ligands in metallothionein confer redox activity on zinc clusters JO - Proc. Natl. Acad. Sci. U. S. A. VL - 95 UR - https://doi.org/10.1073/pnas.95.7.3478 DO - 10.1073/pnas.95.7.3478 ID - Maret1998 ER - TY - JOUR AU - Aizenman, E. AU - Stout, A. K. AU - Hartnett, K. A. AU - Dineley, K. E. AU - McLaughlin, B. AU - Reynolds, I. J. PY - 2000 DA - 2000// TI - Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release JO - J. Neurochem. VL - 75 UR - https://doi.org/10.1046/j.1471-4159.2000.0751878.x DO - 10.1046/j.1471-4159.2000.0751878.x ID - Aizenman2000 ER - TY - JOUR AU - Malaiyandi, L. M. AU - Dineley, K. E. AU - Reynolds, I. J. PY - 2004 DA - 2004// TI - Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release JO - Glia VL - 45 UR - https://doi.org/10.1002/glia.10332 DO - 10.1002/glia.10332 ID - Malaiyandi2004 ER - TY - JOUR AU - Lee, J. Y. AU - Kim, J. H. AU - Palmiter, R. D. AU - Koh, J. Y. PY - 2003 DA - 2003// TI - Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury JO - Exp. Neurol. VL - 184 UR - https://doi.org/10.1016/S0014-4886(03)00382-0 DO - 10.1016/S0014-4886(03)00382-0 ID - Lee2003 ER - TY - JOUR AU - Land, P. W. AU - Aizenman, E. PY - 2005 DA - 2005// TI - Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons JO - Eur. J. Neurosci. VL - 21 UR - https://doi.org/10.1111/j.1460-9568.2005.03903.x DO - 10.1111/j.1460-9568.2005.03903.x ID - Land2005 ER - TY - JOUR AU - Dineley, K. E. AU - Votyakova, T. V. AU - Reynolds, I. J. PY - 2003 DA - 2003// TI - Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration JO - J. Neurochem. VL - 85 UR - https://doi.org/10.1046/j.1471-4159.2003.01678.x DO - 10.1046/j.1471-4159.2003.01678.x ID - Dineley2003 ER - TY - JOUR AU - Chang, D. T. AU - Honick, A. S. AU - Reynolds, I. J. PY - 2006 DA - 2006// TI - Mitochondrial trafficking to synapses in cultured primary cortical neurons JO - J. Neurosci. VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.1012-06.2006 DO - 10.1523/JNEUROSCI.1012-06.2006 ID - Chang2006 ER - TY - JOUR AU - Cai, A. L. AU - Zipfel, G. J. AU - Sheline, C. T. PY - 2006 DA - 2006// TI - Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway JO - Eur. J. Neurosci. VL - 24 UR - https://doi.org/10.1111/j.1460-9568.2006.05110.x DO - 10.1111/j.1460-9568.2006.05110.x ID - Cai2006 ER - TY - JOUR AU - Jiang, D. AU - Sullivan, P. G. AU - Sensi, S. L. AU - Steward, O. AU - Weiss, J. H. PY - 2001 DA - 2001// TI - Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria JO - J. Biol. Chem. VL - 276 UR - https://doi.org/10.1074/jbc.M108834200 DO - 10.1074/jbc.M108834200 ID - Jiang2001 ER - TY - JOUR AU - Sensi, S. L. PY - 2003 DA - 2003// TI - Modulation of mitochondrial function by endogenous Zn2+ pools JO - Proc. Natl. Acad. Sci. U. S. A. VL - 100 UR - https://doi.org/10.1073/pnas.1031598100 DO - 10.1073/pnas.1031598100 ID - Sensi2003 ER - TY - JOUR AU - Cheng, E. H. AU - Kirsch, D. G. AU - Clem, R. J. PY - 1997 DA - 1997// TI - Conversion of Bcl-2 to a Bax-like death effector by caspases JO - Science VL - 278 UR - https://doi.org/10.1126/science.278.5345.1966 DO - 10.1126/science.278.5345.1966 ID - Cheng1997 ER - TY - JOUR AU - Jonas, E. A. AU - Hickman, J. A. AU - Hardwick, J. M. AU - Kaczmarek, L. K. PY - 2005 DA - 2005// TI - Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse JO - J. Biol. Chem. VL - 280 UR - https://doi.org/10.1074/jbc.M410661200 DO - 10.1074/jbc.M410661200 ID - Jonas2005 ER - TY - JOUR AU - Bonanni, L. PY - 2006 DA - 2006// TI - Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain JO - J. Neurosci. VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.5444-05.2006 DO - 10.1523/JNEUROSCI.5444-05.2006 ID - Bonanni2006 ER - TY - JOUR AU - McLaughlin, B. PY - 2001 DA - 2001// TI - p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis JO - J. Neurosci. VL - 21 UR - https://doi.org/10.1523/JNEUROSCI.21-10-03303.2001 DO - 10.1523/JNEUROSCI.21-10-03303.2001 ID - McLaughlin2001 ER - TY - JOUR AU - Du, S. AU - McLaughlin, B. AU - Pal, S. AU - Aizenman, E. PY - 2002 DA - 2002// TI - In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway JO - J. Neurosci. VL - 22 UR - https://doi.org/10.1523/JNEUROSCI.22-17-07408.2002 DO - 10.1523/JNEUROSCI.22-17-07408.2002 ID - Du2002 ER - TY - JOUR AU - Zhang, Y. PY - 2004 DA - 2004// TI - Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation JO - J. Neurosci. VL - 24 UR - https://doi.org/10.1523/JNEUROSCI.2469-04.2004 DO - 10.1523/JNEUROSCI.2469-04.2004 ID - Zhang2004 ER - TY - JOUR AU - Zhang, Y. PY - 2006 DA - 2006// TI - Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes JO - J. Biol. Chem. VL - 281 UR - https://doi.org/10.1074/jbc.M510650200 DO - 10.1074/jbc.M510650200 ID - Zhang2006 ER - TY - JOUR AU - Pal, S. AU - Hartnett, K. A. AU - Nerbonne, J. M. AU - Levitan, E. S. AU - Aizenman, E. PY - 2003 DA - 2003// TI - Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels JO - J. Neurosci. VL - 23 UR - https://doi.org/10.1523/JNEUROSCI.23-12-04798.2003 DO - 10.1523/JNEUROSCI.23-12-04798.2003 ID - Pal2003 ER - TY - JOUR AU - Pal, S. K. AU - Takimoto, K. AU - Aizenman, E. AU - Levitan, E. S. PY - 2006 DA - 2006// TI - Apoptotic surface delivery of K+ channels JO - Cell Death Differ. VL - 13 UR - https://doi.org/10.1038/sj.cdd.4401792 DO - 10.1038/sj.cdd.4401792 ID - Pal2006 ER - TY - JOUR AU - Redman, P. T. PY - 2007 DA - 2007// TI - Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1 JO - Proc. Natl. Acad. Sci. U. S. A. VL - 104 UR - https://doi.org/10.1073/pnas.0610159104 DO - 10.1073/pnas.0610159104 ID - Redman2007 ER - TY - JOUR AU - Bossy-Wetzel, E. PY - 2004 DA - 2004// TI - Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels JO - Neuron VL - 41 UR - https://doi.org/10.1016/S0896-6273(04)00015-7 DO - 10.1016/S0896-6273(04)00015-7 ID - Bossy-Wetzel2004 ER - TY - JOUR AU - Pal, S. AU - He, K. AU - Aizenman, E. PY - 2004 DA - 2004// TI - Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link? JO - Pflugers Arch. VL - 448 UR - https://doi.org/10.1007/s00424-004-1256-7 DO - 10.1007/s00424-004-1256-7 ID - Pal2004 ER - TY - JOUR AU - Xia, Z. AU - Dickens, M. AU - Raingeaud, J. AU - Davis, R. J. AU - Greenberg, M. E. PY - 1995 DA - 1995// TI - Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis JO - Science VL - 270 UR - https://doi.org/10.1126/science.270.5240.1326 DO - 10.1126/science.270.5240.1326 ID - Xia1995 ER - TY - JOUR AU - Chu, C. T. AU - Levinthal, D. J. AU - Kulich, S. M. AU - Chalovich, E. M. AU - Franco, D. B. PY - 2004 DA - 2004// TI - Oxidative neuronal injury. The dark side of ERK1/2 JO - Eur. J. Biochem. VL - 271 UR - https://doi.org/10.1111/j.1432-1033.2004.04132.x DO - 10.1111/j.1432-1033.2004.04132.x ID - Chu2004 ER - TY - JOUR AU - Park, J. A. AU - Koh, J. Y. PY - 1999 DA - 1999// TI - Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death JO - J. Neurochem. VL - 73 UR - https://doi.org/10.1046/j.1471-4159.1999.0730450.x DO - 10.1046/j.1471-4159.1999.0730450.x ID - Park1999 ER - TY - JOUR AU - Noh, K. M. AU - Koh, J. Y. PY - 2000 DA - 2000// TI - Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes JO - J. Neurosci. VL - 20 UR - https://doi.org/10.1523/JNEUROSCI.20-23-j0001.2000 DO - 10.1523/JNEUROSCI.20-23-j0001.2000 ID - Noh2000 ER - TY - JOUR AU - Kim, Y. H. AU - Koh, J. Y. PY - 2002 DA - 2002// TI - The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture JO - Exp. Neurol. VL - 177 UR - https://doi.org/10.1006/exnr.2002.7990 DO - 10.1006/exnr.2002.7990 ID - Kim2002 ER - TY - JOUR AU - Kohda, Y. PY - 2006 DA - 2006// TI - Involvement of Raf-1/MEK/ERK1/2 signaling pathway in zinc-induced injury in rat renal cortical slices JO - J. Toxicol. Sci. VL - 31 UR - https://doi.org/10.2131/jts.31.207 DO - 10.2131/jts.31.207 ID - Kohda2006 ER - TY - JOUR AU - Stanciu, M. PY - 2000 DA - 2000// TI - Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures JO - J. Biol. Chem. VL - 275 UR - https://doi.org/10.1074/jbc.275.16.12200 DO - 10.1074/jbc.275.16.12200 ID - Stanciu2000 ER - TY - JOUR AU - Luo, Y. AU - Franco, D. B. PY - 2006 DA - 2006// TI - Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress JO - J. Biol. Chem. VL - 281 UR - https://doi.org/10.1074/jbc.M512430200 DO - 10.1074/jbc.M512430200 ID - Luo2006 ER - TY - JOUR AU - Shimizu, T. AU - Wolfe, L. S. PY - 1990 DA - 1990// TI - Arachidonic acid cascade and signal transduction JO - J. Neurochem. VL - 55 UR - https://doi.org/10.1111/j.1471-4159.1990.tb08813.x DO - 10.1111/j.1471-4159.1990.tb08813.x ID - Shimizu1990 ER - TY - JOUR AU - Kudo, I. AU - Murakami, M. PY - 2002 DA - 2002// TI - Phospholipase A2 enzymes JO - Prostaglandins Other Lipid Medial VL - 68–69 UR - https://doi.org/10.1016/S0090-6980(02)00020-5 DO - 10.1016/S0090-6980(02)00020-5 ID - Kudo2002 ER - TY - JOUR AU - Li, Y. AU - Maher, P. AU - Schubert, D. PY - 1997 DA - 1997// TI - Arole for 12-lipoxygenase in nerve cell death caused by glutathione depletion JO - Neuron VL - 19 UR - https://doi.org/10.1016/S0896-6273(00)80953-8 DO - 10.1016/S0896-6273(00)80953-8 ID - Li1997 ER - TY - JOUR AU - Leyen, K. AU - Kim, H. Y. AU - Lee, S. R. AU - Jin, G. AU - Arai, K. AU - Lo, E. H. PY - 2006 DA - 2006// TI - Baicalein and 12/15-lipoxygenase in the ischemic brain JO - Stroke VL - 37 UR - https://doi.org/10.1161/01.STR.0000249004.25444.a5 DO - 10.1161/01.STR.0000249004.25444.a5 ID - Leyen2006 ER - TY - JOUR AU - Khanna, S. PY - 2005 DA - 2005// TI - Neuroprotective properties of the natural vitamin E alpha-tocotrienol JO - Stroke VL - 36 UR - https://doi.org/10.1161/01.STR.0000181082.70763.22 DO - 10.1161/01.STR.0000181082.70763.22 ID - Khanna2005 ER - TY - JOUR AU - Koh, J. Y. AU - Suh, S. W. AU - Gwag, B. J. AU - He, Y. Y. AU - Hsu, C. Y. AU - Choi, D. W. PY - 1996 DA - 1996// TI - The role of zinc in selective neuronal death after transient global cerebral ischemia JO - Science VL - 272 UR - https://doi.org/10.1126/science.272.5264.1013 DO - 10.1126/science.272.5264.1013 ID - Koh1996 ER - TY - JOUR AU - Stork, C. J. AU - Li, Y. V. PY - 2006 DA - 2006// TI - Intracellular zinc elevation measured with a “calcium-specific” indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload JO - J. Neurosci. VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.1588-06.2006 DO - 10.1523/JNEUROSCI.1588-06.2006 ID - Stork2006 ER - TY - JOUR AU - Wang, H. PY - 2004 DA - 2004// TI - 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes JO - Eur. J. Neurosci. VL - 20 UR - https://doi.org/10.1111/j.1460-9568.2004.03650.x DO - 10.1111/j.1460-9568.2004.03650.x ID - Wang2004 ER - TY - JOUR AU - Meng, T. C. AU - Fukada, T. AU - Tonks, N. K. PY - 2002 DA - 2002// TI - Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo JO - Mol. Cell VL - 9 UR - https://doi.org/10.1016/S1097-2765(02)00445-8 DO - 10.1016/S1097-2765(02)00445-8 ID - Meng2002 ER - TY - JOUR AU - Tonks, N. K. PY - 2003 DA - 2003// TI - PTP1B: from the sidelines to the front lines! JO - FEBS Lett. VL - 546 UR - https://doi.org/10.1016/S0014-5793(03)00603-3 DO - 10.1016/S0014-5793(03)00603-3 ID - Tonks2003 ER - TY - JOUR AU - Levinthal, D. J. AU - Defranco, D. B. PY - 2005 DA - 2005// TI - Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons JO - J. Biol. Chem. VL - 280 UR - https://doi.org/10.1074/jbc.M410771200 DO - 10.1074/jbc.M410771200 ID - Levinthal2005 ER - TY - JOUR AU - Ho, Y. AU - Logue, E. AU - Callaway, C. W. AU - Defranco, D. B. PY - 2007 DA - 2007// TI - Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion JO - Neuroscience VL - 145 UR - https://doi.org/10.1016/j.neuroscience.2006.11.039 DO - 10.1016/j.neuroscience.2006.11.039 ID - Ho2007 ER -