|
Elderly controls (n = 218)
|
CS1 patients (without cerebrovascular episodes) (n = 188)
|
CS2 patients (n = 100)
|
---|
|
n
|
Frequency
|
n
|
Frequency
|
n
|
Frequency
|
---|
Genotypes
| | | | | | |
GG (C−)
|
122
|
0.56
|
124
|
0.66
|
73
|
0.73
|
CG (C +)
|
81
|
0.37
|
57
|
0.30
|
22
|
0.22
|
CC (C +)
|
15
|
0.07
|
7
|
0.04
|
5
|
0.05
|
Total
|
218
| |
188
| |
100
| |
Alleles
| | | | | | |
G allele
|
325
|
0.75
|
305
|
0.81
|
168
|
0.84
|
C allele
|
111
|
0.25
|
71
|
0.19
|
32
|
0.16
|
Total
|
436
| |
376
| |
200
| |
- aPatients and controls were in Hardy Weinberg equilibrium (P > 0.05). Significant differences of +838 C/G MT2A genotype distributions were observed between CS1 patients, CS2 patients, and elderly controls (Χ2 = 10.612, df = 4, P= .031), and between CS2 patients and elderly controls (Χ2 = 8.492, df = 2, P = .014). However, the comparison between CS1 and CS2 patients failed to reach statistical significance (Χ2 = 1,498, df = 2, P= .23).
- A significant increment of C− carrier frequencies was observed in CS1 and CS2 patients compared with elderly controls (OR = 1.525; P= .042, 95% CI = 1.019–2.282 and OR = 2.13, P = .004, 95% CI = 1.27–3.56, respectively) as determined by Fisher exact test using the approximation of Woolf. Accordingly, a significant increment of G allele frequency was found in CS1 (OR = 1.47, P = .028, 95% CI = 1.048–2.054) and in CS2 patients (OR = 1.793, P= .008, 95% CI = 1.160–2.771) compared with elderly controls.