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Table 3 +838 C/G MT2A Genotypic and Allelic Frequencies in CS1 and CS2 Patients and Elderly Controlsa

From: The +838 C/G MT2A Polymorphism, Metals, and the Inflammatory/Immune Response in Carotid Artery Stenosis in Elderly People

  Elderly controls (n = 218) CS1 patients (without cerebrovascular episodes) (n = 188) CS2 patients (n = 100)
  n Frequency n Frequency n Frequency
Genotypes       
GG (C−) 122 0.56 124 0.66 73 0.73
CG (C +) 81 0.37 57 0.30 22 0.22
CC (C +) 15 0.07 7 0.04 5 0.05
Total 218   188   100  
Alleles       
G allele 325 0.75 305 0.81 168 0.84
C allele 111 0.25 71 0.19 32 0.16
Total 436   376   200  
  1. aPatients and controls were in Hardy Weinberg equilibrium (P > 0.05). Significant differences of +838 C/G MT2A genotype distributions were observed between CS1 patients, CS2 patients, and elderly controls (Χ2 = 10.612, df = 4, P= .031), and between CS2 patients and elderly controls (Χ2 = 8.492, df = 2, P = .014). However, the comparison between CS1 and CS2 patients failed to reach statistical significance (Χ2 = 1,498, df = 2, P= .23).
  2. A significant increment of C− carrier frequencies was observed in CS1 and CS2 patients compared with elderly controls (OR = 1.525; P= .042, 95% CI = 1.019–2.282 and OR = 2.13, P = .004, 95% CI = 1.27–3.56, respectively) as determined by Fisher exact test using the approximation of Woolf. Accordingly, a significant increment of G allele frequency was found in CS1 (OR = 1.47, P = .028, 95% CI = 1.048–2.054) and in CS2 patients (OR = 1.793, P= .008, 95% CI = 1.160–2.771) compared with elderly controls.