| Elderly controls (n = 218) | CS1 patients (without cerebrovascular episodes) (n = 188) | CS2 patients (n = 100) |
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 | n | Frequency | n | Frequency | n | Frequency |
---|
Genotypes | Â | Â | Â | Â | Â | Â |
GG (C−) | 122 | 0.56 | 124 | 0.66 | 73 | 0.73 |
CG (C +) | 81 | 0.37 | 57 | 0.30 | 22 | 0.22 |
CC (C +) | 15 | 0.07 | 7 | 0.04 | 5 | 0.05 |
Total | 218 | Â | 188 | Â | 100 | Â |
Alleles | Â | Â | Â | Â | Â | Â |
G allele | 325 | 0.75 | 305 | 0.81 | 168 | 0.84 |
C allele | 111 | 0.25 | 71 | 0.19 | 32 | 0.16 |
Total | 436 | Â | 376 | Â | 200 | Â |
- aPatients and controls were in Hardy Weinberg equilibrium (P > 0.05). Significant differences of +838 C/G MT2A genotype distributions were observed between CS1 patients, CS2 patients, and elderly controls (Χ2 = 10.612, df = 4, P= .031), and between CS2 patients and elderly controls (Χ2 = 8.492, df = 2, P = .014). However, the comparison between CS1 and CS2 patients failed to reach statistical significance (Χ2 = 1,498, df = 2, P= .23).
- A significant increment of C− carrier frequencies was observed in CS1 and CS2 patients compared with elderly controls (OR = 1.525; P= .042, 95% CI = 1.019–2.282 and OR = 2.13, P = .004, 95% CI = 1.27–3.56, respectively) as determined by Fisher exact test using the approximation of Woolf. Accordingly, a significant increment of G allele frequency was found in CS1 (OR = 1.47, P = .028, 95% CI = 1.048–2.054) and in CS2 patients (OR = 1.793, P= .008, 95% CI = 1.160–2.771) compared with elderly controls.