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Table 3 +838 C/G MT2A Genotypic and Allelic Frequencies in CS1 and CS2 Patients and Elderly Controlsa

From: The +838 C/G MT2A Polymorphism, Metals, and the Inflammatory/Immune Response in Carotid Artery Stenosis in Elderly People

 

Elderly controls (n = 218)

CS1 patients (without cerebrovascular episodes) (n = 188)

CS2 patients (n = 100)

 

n

Frequency

n

Frequency

n

Frequency

Genotypes

      

GG (C−)

122

0.56

124

0.66

73

0.73

CG (C +)

81

0.37

57

0.30

22

0.22

CC (C +)

15

0.07

7

0.04

5

0.05

Total

218

 

188

 

100

 

Alleles

      

G allele

325

0.75

305

0.81

168

0.84

C allele

111

0.25

71

0.19

32

0.16

Total

436

 

376

 

200

 
  1. aPatients and controls were in Hardy Weinberg equilibrium (P > 0.05). Significant differences of +838 C/G MT2A genotype distributions were observed between CS1 patients, CS2 patients, and elderly controls (Χ2 = 10.612, df = 4, P= .031), and between CS2 patients and elderly controls (Χ2 = 8.492, df = 2, P = .014). However, the comparison between CS1 and CS2 patients failed to reach statistical significance (Χ2 = 1,498, df = 2, P= .23).
  2. A significant increment of C− carrier frequencies was observed in CS1 and CS2 patients compared with elderly controls (OR = 1.525; P= .042, 95% CI = 1.019–2.282 and OR = 2.13, P = .004, 95% CI = 1.27–3.56, respectively) as determined by Fisher exact test using the approximation of Woolf. Accordingly, a significant increment of G allele frequency was found in CS1 (OR = 1.47, P = .028, 95% CI = 1.048–2.054) and in CS2 patients (OR = 1.793, P= .008, 95% CI = 1.160–2.771) compared with elderly controls.