Representative gene network within the 1,072 genes upregulated on day three of pediatric septic shock. The network is approximately centered on a gene node corresponding to Sp1 transcription factor (SP1). The genes within the network correspond functionally to the plasminogen activating cascade, immunity and defense, and complement component (based on the Panther Classification System). See text for network derivation. A network legend and the entire gene list contributing to the network are provided in the supplementary data.