Representative gene network within the 1,283 genes downregulated on day one of pediatric septic shock. The gene network contains eight individual gene nodes corresponding to the major histocompatibility complex. The genes within the network correspond functionally to T cell activation, MHCII-mediated immunity, and MHC antigen (based on the Panther Classification System). See text for network derivation. A network legend and the entire gene list contributing to the network are provided in the supplementary data.