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Table 3A Gene Networks Upregulated Uniquely on Day One

From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock

   Panther Classifications3 D.A.V.I.D. Functional Annotation4
   •Pathway (P value) •Category
   •Biological Process (P value) •Term
Network and Central Node1 Ingenuity Annotations2 •Molecular Function (P value) P value
Network 1 MAPK14 •Inflammatory disease •Oxidative stress response (3.3E-8) •GOTERM_BP_ALL
  •Infectious disease •Immunity and defense (1.3E-12) •Response to pest, pathogen or parasite
  •Cell-cell signaling •Protein kinase (5.3E-5) •1.9E-14
Network 2 STAT3 •Immune response •Inflammation mediated by chemokine and cytokine signaling (2.2E-7) •SP_PIR_KEYWORDS
  •Cellular movement   •Signal
  •Hematologic system development •Immunity and defense (2.6E-13) •6.6E-10
   •Cytokine receptor (1.8E-9)  
Network 3 LYN •Cell-cell signaling •PDGF signaling pathway (1.9E-7) •GOTERM_BP_ALL
  •Tissue morphology •Immunity and defense (1.4E-13) •Response to wounding
  •Cellular movement •Signaling molecule (8.0E-6) •1.1E-7
  1. 1“Central node” is a generic term to describe a given network. The term corresponds to the gene node in a given network having a high degree of connectivity to other nodes in the network. The term is not intended as an indication of network function. MAPK14, mitogen-activated protein kinase 14 (a.k.a. p38 MAP kinaseα); STAT3, signal transducer and activator of transcription 3; LYN, p53/p56 lyn kinase.
  2. 2Based on Ingenuity Pathways Analysis annotations for a given network.
  3. 3Based on Panther Classification System. The most significant pathway, biological process, or molecular function (based on P value) in the Panther Classification System is provided for a given network.
  4. 4Based on the D.A.V.I.D. Functional Annotation Tool. The default parameters in D.A.V.I.D. were used to generate the most significant functional annotation (based on P value) for a given network.