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Table 3B Gene Networks Upregulated Uniquely on Day Three

From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock

   Panther Classifications3 D.A.V.I.D. Functional Annotation4
   • Pathway (P value) • Category
   • Biological Process (P value) • Term
Network and Central Node(s)1 Ingenuity Annotations2 • Molecular Function (P value) P value
Network 1 FOS and IL1A • Immune response • Inflammation mediated by chemokine and cytokine signaling (6.0E-5) • GOTERM_BP_ALL
  • Connective tissue disorders   • Defense response
  • Inflammatory disease   • 7.7E-11
  • Immunity and defense • Cytokine receptor (1.5E-09)  
Network 2 MAPK1 • Cellular movement • Toll receptor signaling pathway (4.0E-10) • SP_PIR_KEYWORDS
  • Hematologic system   • Signal
  Development • Proteolysis (2.9E-12) • 1.3E-9
  • Immune response • Serine protease (3.6E-9)  
Network 3 SP1 • Inflammatory disease • Plasminogen activating cascade (3.3E-4) • SP_PIR_KEYWORDS
  • Hematologic system development   • Direct protein sequencing
   • Immunity and defense (3.2E-8) • 2.7E-9
  • Immune response • Complement component (3.8E-5)  
Network 4 STAT3 and STAT5 • Cellular movement • PDGF signaling pathway (1.4E-10) • SP_PIR_KEYWORDS
  • Cell morphology   • Phosphorylation
  • Cellular function and • Signal transduction (1.2E-16) maintenance • 2.2E-14
   • Non-receptor tyrosine protein kinase (2.6E-09)  
Network 5 NFKB1A • Cell death • Insulin/IGF pathway-protein kinase B signaling pathway (1.7E-7) • GOTERM_MF_ALL
  • Cancer   • Protein binding
  • Hematologic disease • Apoptosis (2.5E-8) • 1.4E-9
   • Membrane traffic protein (1.3E-3)  
  1. 1See Table 3A. FOS, c-fos; IL1A, interleukin 1α; MAPK1, mitogen activated protein kinase one (a.k.a. ERK2); SP1, Sp1 transcription factor; STAT3, signal transducer and activator of transcription 3; STAT5B, signal transducer and activator of transcription factor 5B; NFKB1A, nuclear factor of κ light polypeptide gene enhancer in B-cells α (a.k.a. lκBα).
  2. 2,3,4See Table 3A.