Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock

Table 3B Gene Networks Upregulated Uniquely on Day Three

		Panther Classifications³	D.A.V.I.D. Functional Annotation⁴
		• Pathway (P value)	• Category
		• Biological Process (P value)	• Term
Network and Central Node(s)¹	Ingenuity Annotations²	• Molecular Function (P value)	• P value
Network 1 FOS and IL1A	• Immune response	• Inflammation mediated by chemokine and cytokine signaling (6.0E-5)	• GOTERM_BP_ALL
	• Connective tissue disorders		• Defense response
	• Inflammatory disease		• 7.7E-11
	• Immunity and defense	• Cytokine receptor (1.5E-09)
Network 2 MAPK1	• Cellular movement	• Toll receptor signaling pathway (4.0E-10)	• SP_PIR_KEYWORDS
	• Hematologic system		• Signal
	Development	• Proteolysis (2.9E-12)	• 1.3E-9
	• Immune response	• Serine protease (3.6E-9)
Network 3 SP1	• Inflammatory disease	• Plasminogen activating cascade (3.3E-4)	• SP_PIR_KEYWORDS
	• Hematologic system development		• Direct protein sequencing
		• Immunity and defense (3.2E-8)	• 2.7E-9
	• Immune response	• Complement component (3.8E-5)
Network 4 STAT3 and STAT5	• Cellular movement	• PDGF signaling pathway (1.4E-10)	• SP_PIR_KEYWORDS
	• Cell morphology		• Phosphorylation
	• Cellular function and	• Signal transduction (1.2E-16) maintenance	• 2.2E-14
		• Non-receptor tyrosine protein kinase (2.6E-09)
Network 5 NFKB1A	• Cell death	• Insulin/IGF pathway-protein kinase B signaling pathway (1.7E-7)	• GOTERM_MF_ALL
	• Cancer		• Protein binding
	• Hematologic disease	• Apoptosis (2.5E-8)	• 1.4E-9
		• Membrane traffic protein (1.3E-3)

¹See Table 3A. FOS, c-fos; IL1A, interleukin 1α; MAPK1, mitogen activated protein kinase one (a.k.a. ERK2); SP1, Sp1 transcription factor; STAT3, signal transducer and activator of transcription 3; STAT5B, signal transducer and activator of transcription factor 5B; NFKB1A, nuclear factor of κ light polypeptide gene enhancer in B-cells α (a.k.a. lκBα).
^2,3,4See Table 3A.

ISSN: 1528-3658