Table 4B Gene networks Downregulated Uniquely on Day Three
Network and Central Node(s)1 | Ingenuity Annotations2 | Panther Classifications3 | D.A.V.I.D. Functional Annotation4 |
|---|---|---|---|
|  |  | • Pathway (P value) | • Category |
|  |  | • Biological Process (P value) | • Term |
|  |  | • Molecular Function (P value) | • P value |
Network 1 BCL25 | • Hematologic system development | • T cell activation (1.7E-10) | • SP_PIR_KEYWORDS |
|  | • Immune system development | • T cell mediated immunity (5.3E-14) | • T cell |
|  | • Lymphatic system development | • Immunoglobulin receptor family member (8.3E-9) | • 1.8E-16 |
Network 2 IL8 and GATA3 | • Hematologic system development | • B cell activation (6.3E-6) | • GOTERM_BP_ALL |
|  | • Immune system development | • Granulocyte-mediated immunity (9.8E-5) | • Defense response |
• Lymphatic system development | • Guanyl-nucleotide exchange factor (9.2E-4) |  | • 1.7E-7 |
Network 3 HLA6 | • RNA posttranscriptional modification | • T cell activation (4.5E-4) | • KEGG_PATHWAY |
|  |  | • MHCII-mediated immunity (4.0E-14) | • Antigen processing and presentation |
|  | • Cell-cell signaling |  | • 1.4E-13 |
|  | • Immune response | • MHC antigen (4.5E-11) |  |