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Table 4B Gene networks Downregulated Uniquely on Day Three

From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock

Network and Central Node(s)1 Ingenuity Annotations2 Panther Classifications3 D.A.V.I.D. Functional Annotation4
   • Pathway (P value) • Category
   • Biological Process (P value) • Term
   • Molecular Function (P value) P value
Network 1 BCL25 • Hematologic system development • T cell activation (1.7E-10) • SP_PIR_KEYWORDS
  • Immune system development • T cell mediated immunity (5.3E-14) • T cell
  • Lymphatic system development • Immunoglobulin receptor family member (8.3E-9) • 1.8E-16
Network 2 IL8 and GATA3 • Hematologic system development • B cell activation (6.3E-6) • GOTERM_BP_ALL
  • Immune system development • Granulocyte-mediated immunity (9.8E-5) • Defense response
• Lymphatic system development • Guanyl-nucleotide exchange factor (9.2E-4)   • 1.7E-7
Network 3 HLA6 • RNA posttranscriptional modification • T cell activation (4.5E-4) • KEGG_PATHWAY
   • MHCII-mediated immunity (4.0E-14) • Antigen processing and presentation
  • Cell-cell signaling   • 1.4E-13
  • Immune response • MHC antigen (4.5E-11)  
  1. 1See Table 3A. BCL2, B-cell CLL/lymphoma 2; IL8, interleukin 8; GATA3, GATA binding protein 3; HLA, major histocompatibility complex.
  2. 2,3,4See Table 3A.
  3. 5See table 4A
  4. 6See table 4A