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Table 2 Association of the Genotypes and Haplotypes of the Most Significant Four SNPs Within the Large Third Intron of STAT4 with RA Susceptibility

From: Association of STAT4 with Rheumatoid Arthritis in the Korean Population

     Dominanta Alleleb
SNPs Genotype RA Control P value OR (95% CI) OR (95% CI)
rs11889341 TT 149 91 0.0039 1.29 1.27
      (1.08–1.53) (1.12–1.45)
  CT 485 414    
  CC 484 496    
rs7574865 TT 157 95 0.0065 1.29 1.27
      (1.07–1.54) (1.11–1.45)
  GT 481 411    
  GG 394 402    
rs8179673 CC 172 113 0.0181 1.23 1.22
      (1.04–1.47) (1.07–1.38)
  CT 520 456    
  TT 424 430    
rs10181656 GG 172 114 0.0234 1.22 1.21
      (1.03–1.46) (1.07–1.37)
  CG 521 458    
  CC 424 428    
  Frequency P ORs   
Haplotypes RA Control value (95% CI)   
C,G,T,C 0.60 0.64 0.003 0.83(0.73–0.94)   
T,T,C,G 0.34 0.28 0.0027 1.33(1.10–1.60)   
C,T,C,G 0.05 0.05 0.45 0.90(0.68–1.19)   
T,G,T,C 0.0122 0.0126 0.80 0.93(0.53–1.64)   
C,G,C,G 0.0015 0.0026 0.48c 0.73(0.30–1.77)c   
T,G,C,G 0.0014 0.0019     
C,G,T,G 0.0009 0.0015     
C,G,C,C 0.0004 0     
  1. aHomozygote of risk allele and heterozygote versus homozygote of non-risk allele.
  2. bP values are the same as ones in Table S1 (0.0003, 0.0004, 0.002, and 0.0029 in order).
  3. cFour minor haplotypes (CGCG, TGCG, CGTG, and CGCC) are combined to calculate P value and ORs (95% CI).