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Table 2 Association of the Genotypes and Haplotypes of the Most Significant Four SNPs Within the Large Third Intron of STAT4 with RA Susceptibility

From: Association of STAT4 with Rheumatoid Arthritis in the Korean Population

    

Dominanta

Alleleb

SNPs

Genotype

RA

Control

P value

OR (95% CI)

OR (95% CI)

rs11889341

TT

149

91

0.0039

1.29

1.27

     

(1.08–1.53)

(1.12–1.45)

 

CT

485

414

   
 

CC

484

496

   

rs7574865

TT

157

95

0.0065

1.29

1.27

     

(1.07–1.54)

(1.11–1.45)

 

GT

481

411

   
 

GG

394

402

   

rs8179673

CC

172

113

0.0181

1.23

1.22

     

(1.04–1.47)

(1.07–1.38)

 

CT

520

456

   
 

TT

424

430

   

rs10181656

GG

172

114

0.0234

1.22

1.21

     

(1.03–1.46)

(1.07–1.37)

 

CG

521

458

   
 

CC

424

428

   
 

Frequency

P

ORs

  

Haplotypes

RA

Control

value

(95% CI)

  

C,G,T,C

0.60

0.64

0.003

0.83(0.73–0.94)

  

T,T,C,G

0.34

0.28

0.0027

1.33(1.10–1.60)

  

C,T,C,G

0.05

0.05

0.45

0.90(0.68–1.19)

  

T,G,T,C

0.0122

0.0126

0.80

0.93(0.53–1.64)

  

C,G,C,G

0.0015

0.0026

0.48c

0.73(0.30–1.77)c

  

T,G,C,G

0.0014

0.0019

    

C,G,T,G

0.0009

0.0015

    

C,G,C,C

0.0004

0

    
  1. aHomozygote of risk allele and heterozygote versus homozygote of non-risk allele.
  2. bP values are the same as ones in Table S1 (0.0003, 0.0004, 0.002, and 0.0029 in order).
  3. cFour minor haplotypes (CGCG, TGCG, CGTG, and CGCC) are combined to calculate P value and ORs (95% CI).