Figure 2

Decrease in angiogenic response in diabetes is dependent on the presence of RAGE. Angiogenic response in control and streptozotocin-induced diabetic RAGE +/+ or RAGE −/− mice was evaluated through the matrigel assay. VEGF (300 ng/mL) was suspended in matrigel, and the matrigel plugs were implanted subcutaneously into the abdominal midline of 13-week-old mice. The plugs were removed two weeks later, and processed for histochemical analysis. Bars represent 50 µm. Summary of the quantitative analyses is shown in the right panel. Data are shown as mean ± SD. *P < 0.05 vs. control, ANOVA with multiple comparison (Scheffe type). Modified from Figure 2 in (30).