Figure 5

Plasma esRAGE level was inversely correlated with carotid and femoral atherosclerosis in a nondiabetic population but not in a diabetic population. Atherosclerosis was determined as intimal-medial thickness measured by arterial ultrasound. N = 337 including 203 type 2 diabetic patients. For the carotid artery, plasma esRAGE level exhibited a significant inverse correlation with atherosclerosis in nondiabetic subjects (r = −0.245, P = .008, n = 134), but not in diabetic subjects (r = 0.007, P = .923, n = 203). Similarly for the femoral artery, plasma esRAGE level exhibited a significant inverse correlation with atherosclerosis in nondiabetic subjects (r = −0,278, P= .003, n = 134), but not in diabetic subjects (r = −0.048, P = .493, n = 203).